L-Tyrosinamide, N-((4-(1,1-dimethylethyl)phenyl)methyl)-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-(phenylmethyl)-

Base Information

Chemical Name:L-Tyrosinamide, N-((4-(1,1-dimethylethyl)phenyl)methyl)-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-(phenylmethyl)-
CAS No.:217171-01-2
Molecular Formula:C38H53N3O3
Molecular Weight:599.86441
Hs Code.:
UNII:Z7UUP5FPKC
DSSTox Substance ID:DTXSID10432752
Nikkaji Number:J1.118.542H
Pharos Ligand ID:BQXLSQFVVCH6
ChEMBL ID:CHEMBL299749
Mol file:217171-01-2.mol

Synonyms:PD 173212;PD-173212

Suppliers and Price of L-Tyrosinamide, N-((4-(1,1-dimethylethyl)phenyl)methyl)-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-(phenylmethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
PD 173212
10mg
$ 573.00

TRC
PD173212
10mg
$ 345.00

Tocris
PD173212 ≥98%(HPLC)
10
$ 308.00

ChemScene
PD173212 95.01%
10mg
$ 318.00

ChemScene
PD173212 95.01%
5mg
$ 216.00

ChemScene
PD173212 95.01%
2mg
$ 120.00

Cayman Chemical
PD 173212
1mg
$ 47.00

Cayman Chemical
PD 173212
500μg
$ 26.00

Cayman Chemical
PD 173212
5mg
$ 143.00

ApexBio Technology
PD173212
2mg
$ 158.00

Total 7 raw suppliers

Chemical Property of L-Tyrosinamide, N-((4-(1,1-dimethylethyl)phenyl)methyl)-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-(phenylmethyl)-

Chemical Property:

Boiling Point:753.4±60.0 °C(Predicted)
PKA:13.83±0.46(Predicted)
PSA：70.67000
Density:1.053±0.06 g/cm3(Predicted)
LogP:7.83360
Storage Temp.:Store at +4°C
XLogP3:8.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:15
Exact Mass:599.40869256
Heavy Atom Count:44
Complexity:854

Purity/Quality:

97% ^*data from raw suppliers

PD 173212 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)CC(C(=O)NC(CC1=CC=C(C=C1)OCC2=CC=CC=C2)C(=O)NC(C)(C)C)N(C)CC3=CC=C(C=C3)C(C)(C)C
Isomeric SMILES:CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)OCC2=CC=CC=C2)C(=O)NC(C)(C)C)N(C)CC3=CC=C(C=C3)C(C)(C)C
Description PD 173212 is an N-type calcium channel blocker (IC50 = 36 nM). It prevents audiogenic seizures in mice when administered at a dose of 30 mg/kg.

Technology Process of L-Tyrosinamide, N-((4-(1,1-dimethylethyl)phenyl)methyl)-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-(phenylmethyl)-

There total 7 articles about L-Tyrosinamide, N-((4-(1,1-dimethylethyl)phenyl)methyl)-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 217172-81-1
4-methyl-2-methylamino-pentanoic acid [2-(4-benzyloxy-phenyl)-1-tert-butylcarbamoyl-ethyl]-amide

: 18880-00-7
1-(bromomethyl)-4-(1,1-dimethylethyl)benzene

: 217171-01-2
2-[(4-tert-Butyl-benzyl)-methyl-amino]-4-methyl-pentanoic acid [2-(4-benzyloxy-phenyl)-1-tert-butylcarbamoyl-ethyl]-amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 2130-96-3,54784-43-9
O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

: 217171-01-2
2-[(4-tert-butyl-benzyl)-methyl-amino]-4-methyl-pentanoic acid [2-(4-benzyloxy-phenyl)-1-tert-butylcarbamoyl-ethyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium hexafluorophosphate, (iPr)2NEt / dimethylformamide

2: TFA / CH₂Cl₂

3: O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium hexafluorophosphate, (iPr)2NEt / dimethylformamide

4: TFA / CH₂Cl₂

5: NaBH(OAc)3 / CH₂Cl₂

With sodium tris(acetoxy)borohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(99)00359-5

Reference yield:

: 53363-89-6
N-t-butoxycarbonyl-N-methyl-L-leucine

: 217171-01-2
2-[(4-tert-butyl-benzyl)-methyl-amino]-4-methyl-pentanoic acid [2-(4-benzyloxy-phenyl)-1-tert-butylcarbamoyl-ethyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium hexafluorophosphate, (iPr)2NEt / dimethylformamide

2: TFA / CH₂Cl₂

3: NaBH(OAc)3 / CH₂Cl₂

With sodium tris(acetoxy)borohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(99)00359-5