ent Naxagolide Hydrochloride

Base Information

Chemical Name:ent Naxagolide Hydrochloride
CAS No.:100935-99-7
Molecular Formula:C15H21NO2.ClH
Molecular Weight:283.797
Hs Code.:
Mol file:100935-99-7.mol

Synonyms:entNaxagolide Hydrochloride;trans-3,4,4a,5,6,10b-Hexahydro-4-propyl-2H-naphth[1,2-b]-1,4-oxazin-9-ol hydrochloride

Suppliers and Price of ent Naxagolide Hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
ent-NaxagolideHydrochloride
2.5mg
$ 185.00

American Custom Chemicals Corporation
ENT NAXAGOLIDE HYDROCHLORIDE 95.00%
5MG
$ 505.02

Total 5 raw suppliers

Chemical Property of ent Naxagolide Hydrochloride

Chemical Property:

Melting Point:273-275?C (dec.)
PSA：32.70000
LogP:3.23020
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly), Methanol (Slightly, Sonicated)

Purity/Quality:

97% ^*data from raw suppliers

ent-NaxagolideHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses ent Naxagolide Hydrochloride is a dopamine D2-receptor agonist. Used for treatment of extrapyramidal disorders. Antiparkinsonian drug.

Technology Process of ent Naxagolide Hydrochloride

There total 2 articles about ent Naxagolide Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 88058-52-0
trans-N-n-propyl-9-methoxy-2,3,4a,5,6,10b-hexahydro-4H-naphth<1,2b><1,4>oxazine

: 92422-14-5,99705-65-4,100935-99-7,121424-41-7
trans-N-n-propyl-9-hydroxy-2,3,4a,5,6,10b-hexahydro-4H-naphth<1,2b><1,4>oxazine

Guidance literature:: With boron tribromide; In dichloromethane; 2 h, -30-(-40) degC; 20 h, r.t.;

Reference yield:

: 92422-25-8
trans-9-methoxy-2,3,4a,5,6,10b-hexahydro-4H-naphth<1,2-b><1,4>oxazine

: 92422-14-5,99705-65-4,100935-99-7,121424-41-7
trans-N-n-propyl-9-hydroxy-2,3,4a,5,6,10b-hexahydro-4H-naphth<1,2b><1,4>oxazine

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / potassium carbonate / dimethylformamide / 2 h / 55 °C

2: 73 percent / boron tribromide / CH₂Cl₂ / 2 h, -30-(-40) degC; 20 h, r.t.

With boron tribromide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;