ent Naxagolide Hydrochloride

Base Information

• Chemical Name: ent Naxagolide Hydrochloride
• CAS No.: 100935-99-7
• Molecular Formula: C15H21NO2.ClH
• Molecular Weight: 283.797
• Mol file: 100935-99-7.mol

Synonyms:entNaxagolide Hydrochloride;trans-3,4,4a,5,6,10b-Hexahydro-4-propyl-2H-naphth[1,2-b]-1,4-oxazin-9-ol hydrochloride

Chemical Property of ent Naxagolide Hydrochloride

Chemical Property:

• Melting Point: 273-275?C (dec.)
• PSA: 32.70000
• LogP: 3.23020
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly, Sonicated)

Purity/Quality:

97% ^*data from raw suppliers

ent-NaxagolideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: ent Naxagolide Hydrochloride is a dopamine D2-receptor agonist. Used for treatment of extrapyramidal disorders. Antiparkinsonian drug.

Technology Process of ent Naxagolide Hydrochloride

There total 2 articles about ent Naxagolide Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

trans-N-n-propyl-9-methoxy-2,3,4a,5,6,10b-hexahydro-4H-naphth<1,2b><1,4>oxazine (88058-52-0) → trans-N-n-propyl-9-hydroxy-2,3,4a,5,6,10b-hexahydro-4H-naphth<1,2b><1,4>oxazine (92422-14-5,99705-65-4,100935-99-7,121424-41-7)

Guidance literature:

With boron tribromide; In dichloromethane; 2 h, -30-(-40) degC; 20 h, r.t.;

Reference yield:

trans-9-methoxy-2,3,4a,5,6,10b-hexahydro-4H-naphth<1,2-b><1,4>oxazine (92422-25-8) → trans-N-n-propyl-9-hydroxy-2,3,4a,5,6,10b-hexahydro-4H-naphth<1,2b><1,4>oxazine (92422-14-5,99705-65-4,100935-99-7,121424-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / potassium carbonate / dimethylformamide / 2 h / 55 °C

2: 73 percent / boron tribromide / CH₂Cl₂ / 2 h, -30-(-40) degC; 20 h, r.t.

With boron tribromide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

trans-N-n-propyl-9-methoxy-2,3,4a,5,6,10b-hexahydro-4H-naphth<1,2b><1,4>oxazine

trans-9-methoxy-2,3,4a,5,6,10b-hexahydro-4H-naphth<1,2-b><1,4>oxazine