Chemical Property of BRAIN DERIVED NEUROTROPHIC FACTOR, HUMAN
Chemical Property:
- Purity/Quality:
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98%,99%, *data from raw suppliers
Brain Derived Neurotrophic Factor *data from reagent suppliers
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Useful:
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Biological functions
TrkB is expressed in the central and peripheral nervous
systems. A higher level of expression is seen, especially in
the hippocampus, cerebellum, and cerebral cortex. The activation of TrkB induces the survival of neurons, promotes
the development of neuronal circuits, and induces synaptic
plasticity. The function of p75NTR is less clear.
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Description
Brain-derived neurotrophic factor is the second member of the neurotrophin-family trophic factors. BDNF is a polypeptide consisting of 119 amino acid residues, and forms a homodimer. There are two types of receptors binding to BDNF: tropomyosin receptor kinase B (TrkB), the high-affinity receptor, and p75NTR, the low affinity receptor. BDNF regulates the growth, maintenance, and survival of certain target neurons as well as the synaptic plasticity, learning, and memory through the activation of TrkB. On the other hand, the role of p75NTR is less clear.
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Uses
Brain-derived neurotrophic factor (BDNF) recombinant human protein has been used as a supplement in various types of culture media.
