BRAIN DERIVED NEUROTROPHIC FACTOR, HUMAN

Base Information

• Chemical Name: BRAIN DERIVED NEUROTROPHIC FACTOR, HUMAN
• CAS No.: 218441-99-7
• Molecular Formula: C8H11NO4
• Molecular Weight: 0
• Mol file: 218441-99-7.mol

Synonyms:BDNF (human);

Chemical Property of BRAIN DERIVED NEUROTROPHIC FACTOR, HUMAN

Chemical Property:

• Storage Temp.: −20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Brain Derived Neurotrophic Factor ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Biological functions: TrkB is expressed in the central and peripheral nervous systems. A higher level of expression is seen, especially in the hippocampus, cerebellum, and cerebral cortex. The activation of TrkB induces the survival of neurons, promotes the development of neuronal circuits, and induces synaptic plasticity. The function of p75NTR is less clear.
• Description: Brain-derived neurotrophic factor is the second member of the neurotrophin-family trophic factors. BDNF is a polypeptide consisting of 119 amino acid residues, and forms a homodimer. There are two types of receptors binding to BDNF: tropomyosin receptor kinase B (TrkB), the high-affinity receptor, and p75NTR, the low affinity receptor. BDNF regulates the growth, maintenance, and survival of certain target neurons as well as the synaptic plasticity, learning, and memory through the activation of TrkB. On the other hand, the role of p75NTR is less clear.
• Uses: Brain-derived neurotrophic factor (BDNF) recombinant human protein has been used as a supplement in various types of culture media.