5-oxo-2-Piperazinecarboxylic acid

Base Information

• Chemical Name: 5-oxo-2-Piperazinecarboxylic acid
• CAS No.: 3262-59-7
• Molecular Formula: C5H8N2O3
• Molecular Weight: 144.13
• Hs Code.: 2933599090
• Mol file: 3262-59-7.mol

Synonyms:5-oxo-2-Piperazinecarboxylic acid;5-Oxopiperazine-2-carboxylic acid

Chemical Property of 5-oxo-2-Piperazinecarboxylic acid

Chemical Property:

• Melting Point: 154-156℃
• PSA: 81.92000
• Density: 1.343
• LogP: -1.23630
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

5-Oxopiperazine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Oxopiperazine-2-carboxylic Acid is used in preparation of fused Imidazopyrimidinones as Lp-LPA2 inhibitors.

Technology Process of 5-oxo-2-Piperazinecarboxylic acid

There total 1 articles about 5-oxo-2-Piperazinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 5-oxopiperazine-2-carboxylic acid (3262-59-7)

Guidance literature:

(+-)-2,3-Diamino-propionsaeure, Chloressigsaeure-anhydrid, wss.Ba(OH)2;

Reference yield: 27.7%

5-oxopiperazine-2-carboxylic acid (3262-59-7) + benzyl (S)-(1-(3-bromophenyl)but-3-en-1-yl)carbamate → 1-(3-((S)-1-(((benzyloxy)carbonyl)amino)but-3-en-1-yl)phenyl)-5-oxopiperazine-2-carboxylic acid

Guidance literature:

With copper(l) iodide; potassium carbonate; In dimethyl sulfoxide; at 110 ℃; for 48h; Inert atmosphere; Sealed tube;

Reference yield:

5-oxopiperazine-2-carboxylic acid (3262-59-7) → 7-((2,3-difluorobenzyl)oxy)-11,11a-dihydro-1H-pyrazino[1′,2′:3,4]imidazo[1,2-c]pyrimidine-3,9(2H,4H)-dione

Guidance literature:

Multi-step reaction with 5 steps

1: sodium carbonate / ethanol / 50 °C

2: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

3: sodium tetrahydroborate / ethanol / 20 °C

4: triethylamine; methanesulfonyl chloride / tetrahydrofuran / 0.5 h / 0 °C

5: sodium hydride / N,N-dimethyl-formamide / 0.67 h / 23 °C

With sodium tetrahydroborate; sodium hydride; sodium carbonate; potassium carbonate; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;