3-ethyl 5-methyl 2-amino-1H-indole-3,5-dicarboxylate

Base Information

• Chemical Name: 3-ethyl 5-methyl 2-amino-1H-indole-3,5-dicarboxylate
• CAS No.: 521286-73-7
• Molecular Formula: C13H14N2O4
• Molecular Weight: 262
• Hs Code.: 2933990090
• Mol file: 521286-73-7.mol

Synonyms:3-ethyl 5-methyl 2-amino-1H-indole-3,5-dicarboxylate;2-Amino-1H-indole-3,5-dicarboxylic acid 3-ethyl 5-methyl ester;2-AMino-1H-indole-3,5-dicarboxylic acid 3-ethyl ester 5-Methyl ester;Methyl 2-aMino-3-ethoxycarbonyl-1H-indole-5-carboxylate

Chemical Property of 3-ethyl 5-methyl 2-amino-1H-indole-3,5-dicarboxylate

Chemical Property:

• PSA: 94.41000
• Density: 1.335
• LogP: 2.29460

Purity/Quality:

99%, ^*data from raw suppliers

3-ETHYL-5-METHYL-2-AMINO-1H-INDOLE-3,5-DICARBOXYLATE 95.00% ^*data from reagent suppliers

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Technology Process of 3-ethyl 5-methyl 2-amino-1H-indole-3,5-dicarboxylate

There total 1 articles about 3-ethyl 5-methyl 2-amino-1H-indole-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethyl α-cyano-5-methoxycarbonyl-2-nitrophenylacetate (521286-72-6) → methyl 2-amino-3-ethoxycarbonyl-1H-indole-5-carboxylate (521286-73-7)

Guidance literature:

With acetic acid; zinc; at 90 - 100 ℃; for 1h;

Reference yield: 56.0%

methyl 2-amino-3-ethoxycarbonyl-1H-indole-5-carboxylate (521286-73-7) + formamide (77287-34-4,77287-35-5,60100-09-6) → methyl 4-hydroxy-(9H)-pyrimido[4,5-b]indole-6-carboxylate (521286-74-8)

Guidance literature:

With ammonium formate; at 175 ℃;

Reference yield: 53.0%

methyl 2-amino-3-ethoxycarbonyl-1H-indole-5-carboxylate (521286-73-7) + 2-<(3-phenyl-2-propynyl)oxy>benzaldehyde (73179-67-6) → methyl-7-phenyl-6,8-dihydrochromeno[3',4':5,6]pyrido[3,2-b]indole-11-carboxylate

Guidance literature:

With ytterbium(III) triflate; In acetonitrile; at 80 ℃; for 16h; Schlenk technique;

DOI:10.1021/acs.orglett.9b04626

upstream raw materials:

ethyl α-cyano-5-methoxycarbonyl-2-nitrophenylacetate

Downstream raw materials:

methyl 4-hydroxy-(9H)-pyrimido[4,5-b]indole-6-carboxylate

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