2-Chloro-3-(1H-indol-3-yl)-quinoxaline, 98+% C16H10ClN3, MW: 279.73

Base Information

• Chemical Name: 2-Chloro-3-(1H-indol-3-yl)-quinoxaline, 98+% C16H10ClN3, MW: 279.73
• CAS No.: 1146080-41-2
• Molecular Formula: C16H10ClN3
• Molecular Weight: 279.72
• Hs Code.: 2933990090
• Mol file: 1146080-41-2.mol

Synonyms:2-Chloro-3-(1H-indol-3-yl)-quinoxaline;

Chemical Property of 2-Chloro-3-(1H-indol-3-yl)-quinoxaline, 98+% C16H10ClN3, MW: 279.73

Chemical Property:

• PSA: 41.57000
• Density: 1.400
• LogP: 4.43150

Purity/Quality:

≥95% ^*data from raw suppliers

2-Chloro-3-(1H-indol-3-yl)-quinoxaline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-3-(1H-indol-3-yl)-quinoxaline, 98+% C16H10ClN3, MW: 279.73

There total 1 articles about 2-Chloro-3-(1H-indol-3-yl)-quinoxaline, 98+% C16H10ClN3, MW: 279.73 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

indole (120-72-9) + 2,3-dichloroquinoxaline (2213-63-0) → 2-chloro-3-(1H-indol-3-yl)quinoxaline (1146080-41-2)

Guidance literature:

With aluminum (III) chloride; In 1,2-dichloro-ethane; at 80 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.bmc.2012.01.012

Reference yield: 85.0%

2-chloro-3-(1H-indol-3-yl)quinoxaline (1146080-41-2) + phenylacetylene (536-74-3) → 2-(1H-indol-3-yl)-3-(2-phenylethynyl)quinoxaline

Guidance literature:

2-chloro-3-(1H-indol-3-yl)quinoxaline; With copper(l) iodide; palladium 10% on activated carbon; triethylamine; triphenylphosphine; In ethanol; at 20 ℃; for 0.5h; Inert atmosphere;

phenylacetylene; In ethanol; at 20 - 65 ℃; for 9h; Inert atmosphere;

DOI:10.1039/c6ob02340a

upstream raw materials:

indole

2,3-dichloroquinoxaline

Refernces

• 1、 Kumar, K. Shiva,Bhaskar, Boyapally,Ramulu, Meesa Siddi,Kumar, N. Praveen,Ashfaq, Mohd Ashraf,Pal, Manojit. "Metal catalyst free cyclization of 3-alkynyl substituted 2-(indol-3-yl)quinoxalines in TFA alone: a new synthesis of indolophenazines". supporting information. p. 82 - 87. Retrieved 2016/12/27.