1-Benzyl 2-ethyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:1-Benzyl 2-ethyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate
CAS No.:130930-28-8
Molecular Formula:C15H19NO5
Molecular Weight:293.31506
Hs Code.:2933990090
DSSTox Substance ID:DTXSID80562651
Wikidata:Q82446899
Mol file:130930-28-8.mol

Synonyms:1-Benzyl 2-ethyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate;130930-28-8;1-Cbz-trans-4-Hydroxy-L-proline ethyl ester;1-O-benzyl 2-O-ethyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate;1-CBZ-4(R)-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID ETHYL ESTER;SCHEMBL8482480;DTXSID80562651;FEPRPINUVNZMRY-OLZOCXBDSA-N;MFCD09038788;AKOS016007250;CS-0159115;N-CBZ-trans-4-hydroxy-L-proline ethyl ester;A909249;1-benzyl 2-ethyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

Suppliers and Price of 1-Benzyl 2-ethyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
trans-1-Benzyl2-ethyl4-hydroxypyrrolidine-1,2-dicarboxylate 95+%
1g
$ 353.00

Chemenu
1-benzyl2-ethyl(4S)-4-hydroxypyrrolidine-1,2-dicarboxylate 95%
1g
$ 333.00

American Custom Chemicals Corporation
ETHYL (S)-1-CBZ-4-HYDROXY-2-PYRROLIDINECARBOXYLATE 95.00%
5MG
$ 497.34

Alichem
trans-1-Benzyl2-ethyl4-hydroxypyrrolidine-1,2-dicarboxylate
1g
$ 400.00

Total 7 raw suppliers

Chemical Property of 1-Benzyl 2-ethyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate

Chemical Property:

PSA：76.07000
LogP:1.25940
Storage Temp.:2-8°C
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:293.12632271
Heavy Atom Count:21
Complexity:367

Purity/Quality:

98% ^*data from raw suppliers

trans-1-Benzyl2-ethyl4-hydroxypyrrolidine-1,2-dicarboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1CC(CN1C(=O)OCC2=CC=CC=C2)O
Isomeric SMILES:CCOC(=O)[C@@H]1C[C@H](CN1C(=O)OCC2=CC=CC=C2)O

Technology Process of 1-Benzyl 2-ethyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate

There total 1 articles about 1-Benzyl 2-ethyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 130830-64-7
N-(benzyloxycarbonyl)-trans-4-acetoxy-D-proline ethyl ester

: 130930-28-8
N-(benzyloxycarbonyl)-trans-4-hydroxy-D-proline ethyl ester

Guidance literature:: With sodium ethanolate; In ethanol; for 0.333333h; Ambient temperature;
DOI:10.1021/jm00106a037

Reference yield:

: 130930-28-8
N-(benzyloxycarbonyl)-trans-4-hydroxy-D-proline ethyl ester

: 130830-80-7
Mosher amide of cis-4-carboxy-D-proline dimethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / CHCl₃ / 168 h / Ambient temperature

2: 64 percent / dimethylsulfoxide / 80 °C

3: 93 percent / HCl / 84 h / Ambient temperature

4: H₂ / 10percent Pd/C / ethanol / 0.5 h / 2585.7 Torr

5: 16 h / Ambient temperature

With pyridine; hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; chloroform; dimethyl sulfoxide;
DOI:10.1021/jm00106a037

Reference yield:

: 130930-28-8
N-(benzyloxycarbonyl)-trans-4-hydroxy-D-proline ethyl ester

: 130830-76-1
N-(benzyloxycarbonyl)-cis-4-carboxy-D-proline

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / CHCl₃ / 168 h / Ambient temperature

2: 64 percent / dimethylsulfoxide / 80 °C

3: 93 percent / HCl / 84 h / Ambient temperature

4: 96 percent / 4 M NaOH / tetrahydrofuran; H₂O / 0.83 h

With pyridine; hydrogenchloride; sodium hydroxide; In tetrahydrofuran; chloroform; water; dimethyl sulfoxide;
DOI:10.1021/jm00106a037