6-(trifluoroMethoxy)-1H-indole

Base Information

• Chemical Name: 6-(trifluoroMethoxy)-1H-indole
• CAS No.: 467451-91-8
• Molecular Formula: C9H6F3NO
• Molecular Weight: 201.148
• Mol file: 467451-91-8.mol

Synonyms:6-(trifluoromethoxy)-1H-indole;

Chemical Property of 6-(trifluoroMethoxy)-1H-indole

Chemical Property:

• PSA: 25.02000
• LogP: 3.06650
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

6-(Trifluoromethoxy)-1H-indole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Trifluoromethoxy-1H-indole can be used as calcium ion modulators.

Technology Process of 6-(trifluoroMethoxy)-1H-indole

There total 1 articles about 6-(trifluoroMethoxy)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-methyl-α,α,α-trifluoromethoxybenzene (706-27-4) → 6-trifluoromethoxy-1H-indole (467451-91-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; nitric acid / 2.5 h / 0 - 20 °C

2: pyrrolidine / N,N-dimethyl-formamide / 19 h / 105 °C

3: hydrogen / ethanol / 18 h / 20 °C / 3102.97 Torr

With pyrrolidine; sulfuric acid; hydrogen; nitric acid; In ethanol; N,N-dimethyl-formamide;

Reference yield: 70.0%

6-trifluoromethoxy-1H-indole (467451-91-8) + phenylboronic acid (98-80-6) → 3-(phenylthio)-6-(trifluoromethoxy)-1H-indole

Guidance literature:

6-trifluoromethoxy-1H-indole; With palladium diacetate; at 20 ℃; for 0.25h; Ionic liquid; Schlenk technique;

phenylboronic acid; With sulfur; copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; silver carbonate; at 80 ℃; for 6h; Inert atmosphere; Ionic liquid; Schlenk technique;

DOI:10.1021/acs.joc.6b01428

Reference yield:

6-trifluoromethoxy-1H-indole (467451-91-8) → 6-(trifluoromethoxy)indoline (959235-95-1)

Guidance literature:

With sodium cyanoborohydride; acetic acid; for 3h; Ambient temperature;

DOI:10.1021/jm970741j

upstream raw materials:

p-methyl-α,α,α-trifluoromethoxybenzene

Downstream raw materials:

6-(trifluoromethoxy)indoline