4-(3-methoxyphenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one

Base Information

Chemical Name:4-(3-methoxyphenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one
CAS No.:301692-07-9
Molecular Formula:C₂₀H₂₀O₅S
Molecular Weight:372.442
Hs Code.:
Mol file:301692-07-9.mol

Synonyms:4-(3-methoxyphenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one;3(2H)-Furanone, 4-(3-methoxyphenyl)-2,2-dimethyl-5-[4-(methylsulfonyl)phenyl]-;5-(4-Methanesulfonylphenyl)-4-(3-Methoxyphenyl)-2,2-diMethyl-2,3-dihydrofuran-3-one

Suppliers and Price of 4-(3-methoxyphenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(3-methoxyphenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one

Chemical Property:

Melting Point:151-152 °C
Boiling Point:552.8±50.0 °C(Predicted)
PSA：78.05000
Density:1.249±0.06 g/cm3(Predicted)
LogP:4.42570

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 4-(3-methoxyphenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one

There total 8 articles about 4-(3-methoxyphenyl)-2,2-dimethyl-5-(4-(methylsulfonyl)phenyl)furan-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10365-98-7,1107579-37-2
3-methoxyphenylboronic acid

: 301698-97-5
4-bromo-2,2-dimethyl-5-{4-(methylsulfonyl)phenyl}-3(2H)furanone

: 301692-07-9
2,2-Dimethyl-4-(3-methoxyphenyl)-5-{4-(methylsulfonyl)phenyl}-3(2H)-furanone

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; at 90 ℃;
DOI:10.1021/jm020545z

Reference yield:

: 115-19-5
2-methyl-but-3-yn-2-ol

: 301692-07-9
2,2-Dimethyl-4-(3-methoxyphenyl)-5-{4-(methylsulfonyl)phenyl}-3(2H)-furanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C

1.2: 724 mg / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 120 g / MnO₂ / CH₂Cl₂ / 20 h / 20 °C

3.1: 90 mg / Et₂NH / ethanol / 1 h / 20 °C

4.1: 69 mg / AcOH; Br₂ / CCl₄ / 1 h / 20 °C

5.1: 45 mg / OXONE(R) / tetrahydrofuran; ethanol / 20 °C

6.1: Pd(PPh₃)4; aq. Na₂CO₃ / toluene; ethanol / 90 °C

With manganese(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; oxone; bromine; sodium carbonate; acetic acid; diethylamine; In tetrahydrofuran; tetrachloromethane; ethanol; hexane; dichloromethane; toluene; 6.1: Suzuki coupling;
DOI:10.1021/jm020545z

Reference yield:

: 3446-89-7
4-(Methylthio)benzaldehyde

: 301692-07-9
2,2-Dimethyl-4-(3-methoxyphenyl)-5-{4-(methylsulfonyl)phenyl}-3(2H)-furanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C

1.2: 724 mg / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 120 g / MnO₂ / CH₂Cl₂ / 20 h / 20 °C

3.1: 90 mg / Et₂NH / ethanol / 1 h / 20 °C

4.1: 69 mg / AcOH; Br₂ / CCl₄ / 1 h / 20 °C

5.1: 45 mg / OXONE(R) / tetrahydrofuran; ethanol / 20 °C

6.1: Pd(PPh₃)4; aq. Na₂CO₃ / toluene; ethanol / 90 °C

With manganese(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; oxone; bromine; sodium carbonate; acetic acid; diethylamine; In tetrahydrofuran; tetrachloromethane; ethanol; hexane; dichloromethane; toluene; 6.1: Suzuki coupling;
DOI:10.1021/jm020545z