CYCLOPROPANECARBOXAMIDE, 1-AMINO-N-(CYCLOPROPYLSULFONYL)-2-ETHENYL-, HYDROCHLORIDE (1R,2S)-

Base Information

• Chemical Name: CYCLOPROPANECARBOXAMIDE, 1-AMINO-N-(CYCLOPROPYLSULFONYL)-2-ETHENYL-, HYDROCHLORIDE (1R,2S)-
• CAS No.: 630421-49-7
• Molecular Formula: C9H14N2O3S.ClH
• Molecular Weight: 266.747
• Mol file: 630421-49-7.mol

Synonyms:Cyclopropanecarboxamide, 1-amino-N-(cyclopropylsulfonyl)-2-ethenyl-, monohydrochloride, (1R,2S)- (9CI);

Chemical Property of CYCLOPROPANECARBOXAMIDE, 1-AMINO-N-(CYCLOPROPYLSULFONYL)-2-ETHENYL-, HYDROCHLORIDE (1R,2S)-

Chemical Property:

• PSA: 101.13000
• LogP: 2.92160

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CYCLOPROPANECARBOXAMIDE, 1-AMINO-N-(CYCLOPROPYLSULFONYL)-2-ETHENYL-, HYDROCHLORIDE (1R,2S)-

There total 17 articles about CYCLOPROPANECARBOXAMIDE, 1-AMINO-N-(CYCLOPROPYLSULFONYL)-2-ETHENYL-, HYDROCHLORIDE (1R,2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tert-butyl ((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)carbamate (630421-48-6) → (1R,2S)-1-amino-N-(cyclopropylsulfonyl)-2-vinylcyclopropanecarboxamide hydrochloride (630421-49-7)

Guidance literature:

tert-butyl ((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)carbamate; With trifluoroacetic acid; In dichloromethane;

With hydrogenchloride; In diethyl ether;

DOI:10.1021/jm401840s

Reference yield: 92.0%

tert-butyl ((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)carbamate (630421-48-6) → (1R,2S)-1-amino-N-(cyclopropylsulfonyl)-2-ethenylcyclopropanecarboxamide hydrochloride (630421-49-7)

Guidance literature:

tert-butyl ((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

With hydrogenchloride; In diethyl ether;

Reference yield:

→ cyclopropanesulfonic acid (1-amino-2-vinyl-cyclopropanecarbonyl)amide hydrochloride (1258731-89-3,630421-49-7)

Guidance literature:

upstream raw materials:

(1R,2S)-1-amino-N-(cyclopropylsulfonyl)-2-vinylcyclopropane-1-carboxamide

tert-butyl ((1R,2S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)carbamate

tert-butyl ((1R,2R)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-2-vinylcyclopropyl)carbamate

N-Boc-(1R,2S)-1-amino-2-vinylcyclopropane carboxylic acid ethyl ester

Downstream raw materials:

C₃₁H₃₁F₃N₄O₇S

C₃₇H₄₂F₃N₅O₈S

C₄₂H₅₀F₃N₅O₁₀S

tert-butyl (S)-1-((2S,4S)-2-((1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinylcyclopropylcarbamoyl)-4-phenylpyrrolidin-1-yl)-1-oxonon-8-en-2-ylcarbamate