N-(3-Methylpyridin-4-yl)nitramide

Base Information

• Chemical Name: N-(3-Methylpyridin-4-yl)nitramide
• CAS No.: 18227-66-2
• Molecular Formula: C₆H₇N₃O₂
• Molecular Weight: 153.14
• DSSTox Substance ID: DTXSID20463996
• Mol file: 18227-66-2.mol

Synonyms:N-(3-Methylpyridin-4-yl)nitramide;18227-66-2;3-methyl-N-NITROPYRIDIN-4-AMINE;4-Pyridinamine, 3-methyl-N-nitro-;DTXSID20463996;AKOS016007289

Chemical Property of N-(3-Methylpyridin-4-yl)nitramide

Chemical Property:

• PSA: 73.97000
• LogP: 0.93870
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 153.053826475
• Heavy Atom Count: 11
• Complexity: 145

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(3-METHYLPYRIDIN-4-YL)NITRAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CN=C1)N[N+](=O)[O-]

Technology Process of N-(3-Methylpyridin-4-yl)nitramide

There total 4 articles about N-(3-Methylpyridin-4-yl)nitramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-amino-3-methylpyridine (1990-90-5,953018-16-1) → 4-nitramino-3-methylpyridine (18227-66-2)

Guidance literature:

With sulfuric acid; nitric acid; cooling;

DOI:10.1081/NCN-120016477

Reference yield:

3-picoline-N-oxide (1003-73-2) → 4-nitramino-3-methylpyridine (18227-66-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / conc. H₂SO₄; 90 percent HNO₃ / 2 h / below 80 deg C

2: 95 percent / H₂ / Raney Ni / methanol / 4 h / 3361.46 Torr

3: 84 percent / conc. H₂SO₄; conc. HNO₃ / cooling

With sulfuric acid; hydrogen; nitric acid; nickel; In methanol;

DOI:10.1081/NCN-120016477

Reference yield:

3-methyl-4-nitropyridine N-oxide (1074-98-2) → 4-nitramino-3-methylpyridine (18227-66-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / H₂ / Raney Ni / methanol / 4 h / 3361.46 Torr

2: 84 percent / conc. H₂SO₄; conc. HNO₃ / cooling

With sulfuric acid; hydrogen; nitric acid; nickel; In methanol;

DOI:10.1081/NCN-120016477

upstream raw materials:

4-amino-3-methylpyridine

3-picoline-N-oxide

3-methyl-4-nitropyridine N-oxide

Downstream raw materials:

4-amino-3-methyl-5-nitropyridine

4,5-diamino-6-chloro-3-methylpyridine

2'-deoxy-3',5'-di-O-p-toluoyl-7-chloro-4-methyl-1-β-D-ribofuranosyl-3(H)-imidazo[4,5-c]pyridine

2'-deoxy-3',5'-di-O-p-toluoyl-4-chloro-7-methyl-1-β-D-ribofuranosyl-1(H)-imidazo[4,5-c]pyridine