4-BROMO-2,3-DIMETHYLPYRIDINE

Base Information

• Chemical Name: 4-BROMO-2,3-DIMETHYLPYRIDINE
• CAS No.: 259807-91-5
• Molecular Formula: C7H8BrN
• Molecular Weight: 186.04900
• Hs Code.: 2933399090
• Mol file: 259807-91-5.mol

Synonyms:Pyridine,4-bromo-2,3-dimethyl;4-bromo-2,3-dimethyl-pyridine;2,3-DIMETHYL-4-BROMOPYRIDINE;

Chemical Property of 4-BROMO-2,3-DIMETHYLPYRIDINE

Chemical Property:

• Boiling Point: 227.0±35.0 °C(Predicted)
• PKA: 4.61±0.10(Predicted)
• PSA: 12.89000
• Density: 1.415±0.06 g/cm3(Predicted)
• LogP: 2.46090
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-2,3-dimethylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Bromo-2,3-dimethylpyridine is a reagent used in the preparation of propargyl pyridinyl ethers as potential cytochrome P 450 inhibitors.

Technology Process of 4-BROMO-2,3-DIMETHYLPYRIDINE

There total 1 articles about 4-BROMO-2,3-DIMETHYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2,3-dimethylpyridin-4-ol (68707-71-1,89776-31-8) → 4-bromo-2,3-dimethylpyridine (259807-91-5)

Guidance literature:

2,3-dimethylpyridin-4-ol; With phosphorus(V) oxybromide; at 130 ℃; for 4h; Inert atmosphere;

With sodium hydroxide; In water;

Reference yield: 86.0%

4-bromo-2,3-dimethylpyridine (259807-91-5) + ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-en-1-yl)propanoate → ethyl 2-(4-(2,3-dimethylpyridin-4-yl)cyclohex-3-en-1-yl)propanoate

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; sodium carbonate; In 1,4-dioxane; at 100 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acsmedchemlett.1c00236

Reference yield:

4-bromo-2,3-dimethylpyridine (259807-91-5) + (S)-N-(1-(3-bromophenyl)ethyl)-3-chloro-2-methylbenzenesulfonamide → (S)-3-chloro-N-(1-(3-(2,3-dimethylpyridin-4-yl)phenyl)ethyl)-2-methylbenzenesulfonamide

Guidance literature:

(S)-N-(1-(3-bromophenyl)ethyl)-3-chloro-2-methylbenzenesulfonamide; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; bis(pinacol)diborane; In 1,4-dioxane; at 80 ℃; for 18h;

4-bromo-2,3-dimethylpyridine; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; In 1,4-dioxane; at 80 ℃;

upstream raw materials:

2,3-dimethylpyridin-4-ol

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