PF-4942847

Base Information

Chemical Name:PF-4942847
CAS No.:1046859-34-0
Molecular Formula:C₂₀H₁₈Cl₂F₃N₇O₂
Molecular Weight:516.31
Hs Code.:
Mol file:1046859-34-0.mol

Synonyms:PF-4942847;2-aMino-4-(2,4-dichloro-6-(2-(4-fluoro-4,5-dihydropyrazol-1-yl)ethoxy)phenyl)-N-(2,2,2-trifluoroethyl)-5H-pyrrolo[3,4-d]pyriMidine-6(7H)-carboxaMide

Suppliers and Price of PF-4942847

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of PF-4942847

Chemical Property:

PSA：115.41000
Density:1.64
LogP:3.96800

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses A novel potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitor of heat shock protein 90 (Hsp90). It has been shown to induce degradation of multiple client proteins, cell-cycle block, apoptosis, and inhibits cell proliferation in triple-negative breast cancer (TNBC) lines, subsequently leading to tumor growth inhibition in mouse xenograft models.

Technology Process of PF-4942847

There total 12 articles about PF-4942847 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1046859-34-0
2-amino-4-[2,4-dichloro-6-(2-(pyrazol-1-yl)ethoxy)phenyl]-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2,2-trifluoroethyl)amide

Guidance literature:

Reference yield:

: 1046861-47-5
N-(2,2,2-trifluoroethyl)-1H-imidazole-1-carboxamide

: 1046861-69-1
4-[2,4-dichloro-6-(2-(pyrazol-1-yl)ethoxy)phenyl]-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamine hydrogen iodide salt

: 1046859-34-0
2-amino-4-[2,4-dichloro-6-(2-(pyrazol-1-yl)ethoxy)phenyl]-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2,2-trifluoroethyl)amide

Guidance literature:: With triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 60 ℃; for 4h;
DOI:10.1021/jm200128m

Reference yield:

: 1028332-19-5
3,5-dichloro-2-iodophenol

: 1046859-34-0
2-amino-4-[2,4-dichloro-6-(2-(pyrazol-1-yl)ethoxy)phenyl]-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2,2-trifluoroethyl)amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2.1: palladium diacetate; triethylamine; CyJohnPhos / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

3.1: boron tribromide / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

3.2: Cooling

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 4.5 h / 85 °C / Inert atmosphere

5.1: potassium carbonate / dimethyl sulfoxide / 4 h / 55 °C / Inert atmosphere

6.1: trimethylsilyl iodide / chloroform / 24 h / Inert atmosphere; Reflux

7.1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 4 h / 60 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; trimethylsilyl iodide; palladium diacetate; boron tribromide; sodium carbonate; potassium carbonate; triethylamine; CyJohnPhos; In 1,4-dioxane; dichloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 4.1: Suzuki coupling;
DOI:10.1021/jm200128m