3,5-PYRIDINEDIMETHANOL

Base Information

• Chemical Name: 3,5-PYRIDINEDIMETHANOL
• CAS No.: 21636-51-1
• Molecular Formula: C7H9NO2
• Molecular Weight: 139.154
• Mol file: 21636-51-1.mol

Synonyms:3,5-PYRIDINEDIMETHANOL;3,5-Dihydroxymethylpyridine

Chemical Property of 3,5-PYRIDINEDIMETHANOL

Chemical Property:

• Boiling Point: 350.6±32.0 °C(Predicted)
• PKA: 13.40±0.10(Predicted)
• PSA: 53.35000
• Density: 1.261±0.06 g/cm3(Predicted)
• LogP: 0.06620
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

3,5-PYRIDINEDIMETHANOL 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Pyridine-3,5-diyldimethanol is an intermediate for the synthesis of 5’-[(Desloratadine)methyl] Rupatadine (D290270), which is an impurity of the antihistaminic drug Rupatadine (R701650).

Technology Process of 3,5-PYRIDINEDIMETHANOL

There total 6 articles about 3,5-PYRIDINEDIMETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

dimethyl pyridine-3,5-dicarboxylate (4591-55-3) → 3,5-bis(hydroxymethyl)pyridine (21636-51-1)

Guidance literature:

lithium aluminium reduction;

Reference yield: 59.0%

→ 3,5-bis(hydroxymethyl)pyridine (21636-51-1)

Guidance literature:

Reference yield: 49.0%

pyridine-3,5-dicarbonyl dichloride (15074-61-0) → 3,5-bis(hydroxymethyl)pyridine (21636-51-1)

Guidance literature:

With sodium tetrahydroborate; In water; at 0 - 20 ℃; for 1h; Schlenk technique; Inert atmosphere;

DOI:10.1055/s-0033-1338614

upstream raw materials:

diethyl 3,5-pyridinedicarboxylate

dimethyl pyridine-3,5-dicarboxylate

3,5-Lutidine

pyridine-3,5-dicarbonyl dichloride

Downstream raw materials:

3,5-bis(chloromethyl)pyridine

3,5-bis-(bromomethyl)pyridine hydrobromide

3,5-bis-{4-[tris-(4-tert-butyl-phenyl)-methyl]-phenoxymethyl}-pyridine

3,5-Lutidine

Refernces

• 1、 Som, Bozumeh,Smith, Mark D.,Shimizu, Linda S.. "Multi-dimensional copper(I) and silver (I) coordination polymers assembled with a pyridyl bis-urea macrocyclic ligand". . . Retrieved 2021/04/09.
• 2、 -. "NOVEL BENZODIAZEPINE DERIVATIVES AND USES THEREOF". Paragraph 0489-0491. . Retrieved 2019/12/24.