4-Hydroxy-5-methoxy-2-pyridinecarboxylic acid

Base Information

• Chemical Name: 4-Hydroxy-5-methoxy-2-pyridinecarboxylic acid
• CAS No.: 51727-04-9
• Molecular Formula: C7H7NO4
• Molecular Weight: 169.13
• DSSTox Substance ID: DTXSID80474745
• Wikidata: Q82304863
• Mol file: 51727-04-9.mol

Synonyms:4-hydroxy-5-methoxy-2-pyridinecarboxylic acid;51727-04-9;4-hydroxy-5-methoxypicolinic acid;5-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid;4-hydroxy-5-methoxypyridine-2-carboxylic acid;5-methoxy-4-oxo-1H-pyridine-2-carboxylic acid;103878-37-1;AE-562/43286909;SCHEMBL7343126;SCHEMBL15764332;DTXSID80474745;BBL036367;MFCD09965920;STL468886;STL569148;AKOS005208005;AKOS005208590;SB54105;VS-13442;CS-0369125;EN300-238721;A934211;5-methoxy-4-oxo-1,4-dihydropyridine-2-carboxylicacid;F2158-0175;F2158-0448;Z1198280174;4-Hydroxy-5-methoxy-2-pyridinecarboxylic acid, AldrichCPR

Chemical Property of 4-Hydroxy-5-methoxy-2-pyridinecarboxylic acid

Chemical Property:

• Melting Point: 251-253 °C
• Boiling Point: 531.6±50.0 °C(Predicted)
• PKA: 1.27±0.50(Predicted)
• Density: 1.437±0.06 g/cm3(Predicted)
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 169.03750770
• Heavy Atom Count: 12
• Complexity: 290

Purity/Quality:

97% purity ^*data from raw suppliers

4-Hydroxy-5-methoxypicolinicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CNC(=CC1=O)C(=O)O
• Uses: 4-Hydroxy-5-methoxy-2-pyridinecarboxylic acid is used as a reactant in the preparation of ampicillin derivatives substituted with heterocyclic acyl groups.

Technology Process of 4-Hydroxy-5-methoxy-2-pyridinecarboxylic acid

There total 5 articles about 4-Hydroxy-5-methoxy-2-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Hydroxy-2-hydroxymethyl-5-methoxypyridin (62885-42-1) → 4-Hydroxy-5-methoxypyridin-2-carbonsaeure (51727-04-9)

Guidance literature:

With nitric acid;

DOI:10.1039/jr9310003023

Reference yield:

→ 4-Hydroxy-5-methoxypyridin-2-carbonsaeure (51727-04-9)

Guidance literature:

With ammonia; at 100 ℃; im Rohr;

Reference yield:

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one (501-30-4,123712-78-7) → 4-Hydroxy-5-methoxypyridin-2-carbonsaeure (51727-04-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hydroxide; water / 20 °C

1.2: 2 h / 0 - 23 °C

2.1: ammonium hydroxide / water; methanol / 6 h / 100 °C / Sealed tube

3.1: nitric acid / 1 h / 20 °C

With ammonium hydroxide; water; nitric acid; potassium hydroxide; In methanol; water;

upstream raw materials:

4-Hydroxy-2-hydroxymethyl-5-methoxypyridin

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

2-Hydroxymethyl-5-methoxy-4H-pyran-4-on

Refernces

• 1、 -. "HETEROARYLBENZIMIDAZOLE COMPOUNDS". Page/Page column 343. . Retrieved 2017/07/06.