Donepezil IMpurity-IV

Base Information

Chemical Name:Donepezil IMpurity-IV
CAS No.:130927-68-3
Molecular Formula:C24H29NO2
Molecular Weight:399.9535
Hs Code.:
Mol file:130927-68-3.mol

Synonyms:piperidine, 4-[(5,6-dimethoxy-1H-inden-2-yl)methyl]-1-(phenylmethyl)-;

Suppliers and Price of Donepezil IMpurity-IV

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Donepezil IMpurity-IV

Chemical Property:

PSA：21.70000
LogP:4.88350

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Donepezil IMpurity-IV

There total 3 articles about Donepezil IMpurity-IV which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 120012-04-6
1-benzyl-4-[(5,6-dimethoxy-1-indanol)-2-yl]methylpiperidine

: 130927-68-3
1-Benzyl-4-[(5,6-dimethoxyinden)-2-yl]methylpiperidine hydrochloride

Guidance literature:: With hydrogenchloride; In dichloromethane; ethyl acetate;
DOI:10.1021/jm00024a009

Reference yield:

: 1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine hydrochloride

: 130927-68-3
1-Benzyl-4-[(5,6-dimethoxyinden)-2-yl]methylpiperidine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / tetrahydrofuran / 6 h / 760 Torr / Ambient temperature

2: 71 percent / NaBH₄ / methanol / 1.5 h / 0 - 20 °C

3: 95 percent / HCl / ethyl acetate; CH₂Cl₂

With hydrogenchloride; sodium tetrahydroborate; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm00024a009

Reference yield:

: 120014-06-4,142057-79-2,142057-80-5,142698-19-9
donepezil

: 130927-68-3
1-Benzyl-4-[(5,6-dimethoxyinden)-2-yl]methylpiperidine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / NaBH₄ / methanol / 1.5 h / 0 - 20 °C

2: 95 percent / HCl / ethyl acetate; CH₂Cl₂

With hydrogenchloride; sodium tetrahydroborate; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm00024a009