1-Benzyl 2-methyl (2R,4S)-4-hydroxy-1,2-piperidinedicarboxylate

Base Information

Chemical Name:1-Benzyl 2-methyl (2R,4S)-4-hydroxy-1,2-piperidinedicarboxylate
CAS No.:475504-31-5
Molecular Formula:C15H19NO5
Molecular Weight:293.32
Hs Code.:
Mol file:475504-31-5.mol

Synonyms:1,2-Piperidinedicarboxylic acid, 4-hydroxy-,2-methyl 1-(phenylmethyl) ester, (2R,4S)-;1,2-Piperidinedicarboxylic acid, 4-hydroxy-, 2-methyl 1-(phenylmethyl) ester, (2R,4S)-;

Suppliers and Price of 1-Benzyl 2-methyl (2R,4S)-4-hydroxy-1,2-piperidinedicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 1-Benzyl 2-methyl (2R,4S)-4-hydroxy-1,2-piperidinedicarboxylate

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 1-Benzyl 2-methyl (2R,4S)-4-hydroxy-1,2-piperidinedicarboxylate

There total 9 articles about 1-Benzyl 2-methyl (2R,4S)-4-hydroxy-1,2-piperidinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 475504-29-1
(2R)-4-formylpipecolic acid methyl ester

: 475504-31-5,1357348-22-1
(2R,4S)-4-hydroxypipecolic acid methyl ester

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 2h;
DOI:10.1021/op020017x

Reference yield:

: 475504-29-1
(2R)-4-formylpipecolic acid methyl ester

: C₁₆H₁₉NO₆

: 475504-32-6,1357348-22-1
(2R,4R)-4-hydroxypipecolic acid methyl ester

: 475504-31-5,1357348-22-1
(2R,4S)-4-hydroxypipecolic acid methyl ester

Guidance literature:: With tert-butyl methyl ether; chirazyme L₉ (Mucormiehei, Roche); In aq. phosphate buffer; at 20 ℃; for 96h; pH=7; Overall yield = 903 g; Resolution of racemate; Enzymatic reaction;
DOI:10.1021/op020017x

Reference yield:

: 127474-54-8
(R)-2-(benzyloxycarbonylamino)pent-4-enoic acid

: 475504-31-5,1357348-22-1
(2R,4S)-4-hydroxypipecolic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 0 - 20 °C

2: formic acid / 72 h / 25 °C

3: potassium carbonate / methanol / 2 h / 20 °C

With formic acid; thionyl chloride; potassium carbonate; In methanol;
DOI:10.1021/op020017x