Tert-butyl [(1r,2s)-2-ethenyl-1-{[(1-Methylcyclopropyl)sulfonyl]carbaMoyl}cyclopropyl]carbaMate

Base Information

Chemical Name:Tert-butyl [(1r,2s)-2-ethenyl-1-{[(1-Methylcyclopropyl)sulfonyl]carbaMoyl}cyclopropyl]carbaMate
CAS No.:853269-57-5
Molecular Formula:C15H24N2O5S
Molecular Weight:344.42646
Hs Code.:
Mol file:853269-57-5.mol

Synonyms:Tert-butyl [(1r,2s)-2-ethenyl-1-{[(1-Methylcyclopropyl)sulfonyl]carbaMoyl}cyclopropyl]carbaMate;tert-butyl ((1R,2S)-1-(((1-Methylcyclopropyl)sulfonyl)carbaMoyl)-2-vinyl cyclopropyl)carbaMate

Suppliers and Price of Tert-butyl [(1r,2s)-2-ethenyl-1-{[(1-Methylcyclopropyl)sulfonyl]carbaMoyl}cyclopropyl]carbaMate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 16 raw suppliers

Chemical Property of Tert-butyl [(1r,2s)-2-ethenyl-1-{[(1-Methylcyclopropyl)sulfonyl]carbaMoyl}cyclopropyl]carbaMate

Chemical Property:

PKA:4.82±0.40(Predicted)
PSA：116.93000
Density:1.27±0.1 g/cm3(Predicted)
LogP:3.57980

Purity/Quality:: 99%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Tert-butyl [(1r,2s)-2-ethenyl-1-{[(1-Methylcyclopropyl)sulfonyl]carbaMoyl}cyclopropyl]carbaMate

There total 5 articles about Tert-butyl [(1r,2s)-2-ethenyl-1-{[(1-Methylcyclopropyl)sulfonyl]carbaMoyl}cyclopropyl]carbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 669008-26-8
1-methylcyclopropane-1-sulfonamide

: 159622-10-3,213316-50-8,259221-77-7
(1R,2S)-1-(tert-butoxycarbonylamino)-2-vinylcyclopropanecarboxylic acid

: 853269-57-5
tert-butyl [(1R,2S)-2-ethenyl-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]carbamate

Guidance literature:: (1R,2S)-1-(tert-butoxycarbonylamino)-2-vinylcyclopropanecarboxylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 85 ℃; for 0.5h;

1-methylcyclopropane-1-sulfonamide; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield: 77.0%

: 159622-10-3,213316-50-8,259221-77-7
(1R,2S)-1-(tert-butoxycarbonylamino)-2-vinylcyclopropanecarboxylic acid

: 853269-57-5
tert-butyl [(1R,2S)-2-ethenyl-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]carbamate

Guidance literature:: With CDI; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran;

Reference yield:

: 1265883-97-3
methyl N-Boc-(1R,2S)-1-amino-2-vinylcyclopropane-carboxylate tosylate

: 853269-57-5
tert-butyl [(1R,2S)-2-ethenyl-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water; tetrahydrofuran / 72 h / 20 - 50 °C

2.1: di(2H-imidazol-2-yl)methanone / tetrahydrofuran / 2 h / 20 °C / Reflux

2.2: 16 h / 0 - 20 °C

With sodium hydroxide; di(2H-imidazol-2-yl)methanone; In tetrahydrofuran; water;