5α-Androstan-17-one, 3β-hydroxy-, hydrazone

Base Information

• Chemical Name: 5α-Androstan-17-one, 3β-hydroxy-, hydrazone
• CAS No.: 10481-80-8
• Molecular Formula: C19H32N2O
• Molecular Weight: 304.476
• Mol file: 10481-80-8.mol

Synonyms:AND037;Androstan-17-one,3-hydroxy-,hydrazone,(3|A,5|A);

Chemical Property of 5α-Androstan-17-one, 3β-hydroxy-, hydrazone

Chemical Property:

• PSA: 58.61000
• LogP: 4.40500

Purity/Quality:

98%,99%, ^*data from raw suppliers

5α-Androstan-17-one,3β-hydroxy-,hydrazone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5α-Androstan-17-one, 3β-hydroxy-, hydrazone

There total 8 articles about 5α-Androstan-17-one, 3β-hydroxy-, hydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Epiandrosterone (481-29-8) → 3β-hydroxy-17-hydrozone-5α-androstane (10481-80-8)

Guidance literature:

With hydrazine hydrate; for 3h; Reflux;

DOI:10.1016/j.steroids.2010.09.001

Reference yield: 93.0%

Epiandrosterone (481-29-8) → 3β-hydroxy-5α-androstan-17-one hydrazone (10481-80-8,49566-77-0,76023-63-7,88930-99-8)

Guidance literature:

With triethylamine; hydrazine; In ethanol; for 2h; Heating;

DOI:10.1016/S0040-4020(01)82442-X

Reference yield: 87.0%

cis-androsterone (53-41-8) → androsterone hydrazone (10481-80-8,49566-77-0,76023-63-7,88930-99-8)

Guidance literature:

With hydrazine hydrate; In ethanol; for 1h; Heating;

upstream raw materials:

(3α,5α,13α)-3-hydroxyandrostane-17-one

cis-androsterone

Epiandrosterone

3β-acetoxy-5α-androstan-17-one

Downstream raw materials:

cis-androsterone

androsterone azine

17β-iodo-5α-androst-16-en-3β-ol

3β-hydroxy-3'-methyl-4'-(p-tolylhydrazono)-4',5'-dihydropyridazino[5',6':16,17]-5α-androstane

Refernces

• 1、 Koch, Vanessa,Meschkov, Anna,Feuerstein, Wolfram,Pfeifer, Juliana,Fuhr, Olaf,Nieger, Martin,Schepers, Ute,Br?se, Stefan. "Synthesis, Characterization, and Biological Properties of Steroidal Ruthenium(II) and Iridium(III) Complexes Based on the Androst-16-en-3-ol Framework". . p. 15917 - 15926. Retrieved 2019.
• 2、 Gomes, Ligia R.,Low, John N.,Turner, Alan B.,Baddeley, Thomas C.,Wardell, James L.. "Crystal structures and Hirshfeld surface analyses of the di- and tri-hydrates of (5α,17E)-17-hydrazonoandrostan-3-ol: Significant differences in the hydrogen bonding patterns and supramolecular arrangements". . p. 92 - 103. Retrieved 2018/10/20.