Technology Process of 3-Benzofurancarboxylic acid, 2-(4-fluorophenyl)-5-(1-methylethoxy)-, ethyl ester
There total 3 articles about 3-Benzofurancarboxylic acid, 2-(4-fluorophenyl)-5-(1-methylethoxy)-, ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: zinc(II) chloride / toluene; diethyl ether; tetrahydrofuran / 6 h / 110 °C
2: caesium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C
With
caesium carbonate; zinc(II) chloride;
In
tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium tert-butylate / toluene / 1 h / 80 °C
1.2: 18 h / 20 - 70 °C
2.1: zinc(II) chloride / toluene; diethyl ether; tetrahydrofuran / 6 h / 110 °C
3.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C
With
potassium tert-butylate; caesium carbonate; zinc(II) chloride;
In
tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: magnesium chloride / tetrahydrofuran / 18 h / 25 - 65 °C / Inert atmosphere
1.2: 12 h / 25 - 30 °C / Inert atmosphere
2.1: zinc(II) chloride / toluene / 12.5 h / 25 - 120 °C / Inert atmosphere
3.1: 1-methyl-pyrrolidin-2-one; caesium carbonate / 0.5 h / 25 - 30 °C / Inert atmosphere
3.2: 8.5 h / 25 - 80 °C / Inert atmosphere
With
1-methyl-pyrrolidin-2-one; caesium carbonate; magnesium chloride; zinc(II) chloride;
In
tetrahydrofuran; toluene;
DOI:10.1016/j.bmcl.2018.01.029
