Methanone, (4-fluorophenyl)-1H-indol-7-yl-

Base Information

• Chemical Name: Methanone, (4-fluorophenyl)-1H-indol-7-yl-
• CAS No.: 405275-40-3
• Molecular Formula: C15H10FNO
• Molecular Weight: 239.249
• Hs Code.: 2933998090
• Mol file: 405275-40-3.mol

Synonyms:Methanone, (4-fluorophenyl)-1H-indol-7-yl-;(4-Fluorophenyl)(1H-indol-7-yl)methanone

Chemical Property of Methanone, (4-fluorophenyl)-1H-indol-7-yl-

Chemical Property:

• PSA: 32.86000
• LogP: 3.53800
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(4-Fluorophenyl)(1H-indol-7-yl)methanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of Methanone, (4-fluorophenyl)-1H-indol-7-yl-

There total 10 articles about Methanone, (4-fluorophenyl)-1H-indol-7-yl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

→ (4-fluorophenyl)(1H-indol-7-yl)methanone (405275-40-3)

Guidance literature:

Reference yield: 89.0%

pyrrole (109-97-7,30604-81-0) + (E)-4-diazo-5-(4-fluorophenyl)-5-oxopent-2-enal (1616777-24-2) → (4-fluorophenyl)(1H-indol-7-yl)methanone (405275-40-3)

Guidance literature:

With dirhodium tetraacetate; In dichloromethane; at 20 ℃; for 4h; regioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201400161

Reference yield: 76.9%

1H-indole-7-carbonitrile (96631-87-7) + 4-fluoroboronic acid (1765-93-1) → (4-fluorophenyl)(1H-indol-7-yl)methanone (405275-40-3)

Guidance literature:

With 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid; palladium(II) trifluoroacetate; In 2-methyltetrahydrofuran; water; at 80 ℃; for 35h;

upstream raw materials:

7-(4-fluorobenzoyl)-1H-indoline

1-indoline

4-fluorobenzonitrile

5-((tert-butyldimethylsilyl)oxy)-1-(4-fluorophenyl)pent-2-en-1-one

Downstream raw materials:

(1-ethyl-1H-indol-7-yl)-(4-fluoro-phenyl)-methanone

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