Carbamic acid, (3-amino-2,6-difluorophenyl)-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, (3-amino-2,6-difluorophenyl)-, 1,1-dimethylethyl ester
• CAS No.: 535170-20-8
• Molecular Formula: C11H14F2N2O2
• Molecular Weight: 244.241
• Hs Code.: 2924297099
• Mol file: 535170-20-8.mol

Synonyms:CarbaMic acid, (3-aMino-2,6-difluorophenyl)-, 1,1-diMethylethyl ester;tert-Butyl (3-amino-2,6-difluorophenyl)carbamate

Chemical Property of Carbamic acid, (3-amino-2,6-difluorophenyl)-, 1,1-dimethylethyl ester

Chemical Property:

• Boiling Point: 270.8±40.0 °C(Predicted)
• PKA: 11.40±0.70(Predicted)
• PSA: 64.35000
• Density: 1.291±0.06 g/cm3(Predicted)
• LogP: 3.54820
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

tert-Butyl (3-amino-2,6-difluorophenyl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, (3-amino-2,6-difluorophenyl)-, 1,1-dimethylethyl ester

There total 7 articles about Carbamic acid, (3-amino-2,6-difluorophenyl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

tert-butyl (2,6-difluoro-3-nitrophenyl)carbamate (535170-17-3) → tert-butyl (3-amino-2,6-difluorophenyl)carbamate (535170-20-8)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; for 15h;

Reference yield:

2,6-difluoro-3-nitrobenzoic acid (83141-10-0) → tert-butyl (3-amino-2,6-difluorophenyl)carbamate (535170-20-8)

Guidance literature:

Multi-step reaction with 4 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 20 °C

2: sodium azide / CH₂Cl₂; dimethylformamide / 20 °C

3: CH₂Cl₂; dimethylformamide / Heating

4: 38 percent / H₂ / palladium black / methanol / 20 °C

With sodium azide; oxalyl dichloride; hydrogen; N,N-dimethyl-formamide; palladium; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm0205090

Reference yield:

2,6-difluoro-3-nitrobenzoic acid chloride (260552-98-5) → tert-butyl (3-amino-2,6-difluorophenyl)carbamate (535170-20-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium azide / CH₂Cl₂; dimethylformamide / 20 °C

2: CH₂Cl₂; dimethylformamide / Heating

3: 38 percent / H₂ / palladium black / methanol / 20 °C

With sodium azide; hydrogen; palladium; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm0205090

upstream raw materials:

tert-butyl (2,6-difluoro-3-nitrophenyl)carbamate

2,6-difluoro-3-nitrobenzoic acid

2,6-difluoro-3-nitrobenzoic acid chloride

2,6-difluorobenzoic acid

Downstream raw materials:

tert-butyl 2,6-difluoro-3-(1-methyl-1H-imidazole-4-sulfonamido)phenylcarbamate

benzyl tert-butyl (2,4-difluoro-1,3-phenylene)dicarbamate

tert-butyl 2,6-difluoro-3-(1-methylethylsulfonamido)phenylcarbamate

1-(3-amino-2,4-difluorophenyl)-7-[(3S)-3-aminopyrrolidin-1-yl]-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

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