2H-Pyrazolo[4,3-b]pyridine

Base Information

• Chemical Name: 2H-Pyrazolo[4,3-b]pyridine
• CAS No.: 272-51-5
• Molecular Formula: C6H5N3
• Molecular Weight: 119.12
• Hs Code.: 2933399990
• Mol file: 272-51-5.mol

Synonyms:4-Aza-2H-indazole;2H-Pyrazolo[4,3-b]pyridine

Chemical Property of 2H-Pyrazolo[4,3-b]pyridine

Chemical Property:

• PKA: 11?+-.0.30(Predicted)
• Density: 1.348±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

2H-Pyrazolo[4,3-b]pyridine ^*data from reagent suppliers

Safty Information:

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Useful:

• General Description: 2H-Pyrazolo[4,3-b]pyridine serves as a core structure in the design of novel allosteric modulators targeting chemokine receptors CXCR3 and CXCR4, which are implicated in immune regulation and disease pathways. Derivatives of this scaffold, such as compound **9e**, demonstrate dual negative modulation of both receptors, while others exhibit selective activity—either as potent negative modulators (e.g., **7a**, **7g**, **9c**), modest positive modulators (e.g., **13a**), or weak agonists (e.g., **6a**, **6b**) of CXCR4. These findings highlight its utility in developing therapeutics for inflammation, autoimmune disorders, and cancer by fine-tuning receptor interactions.

Refernces

Insight into structural requirements for selective and/or dual CXCR3 and CXCR4 allosteric modulators

10.1016/j.ejmech.2018.05.013

This research aims to design, synthesize, and biologically evaluate a series of novel allosteric modulators based on a pyrazolopyridine core for the chemokine receptors CXCR3 and CXCR4, which play crucial roles in immune response and various diseases. The study identified compound 9e as a dual negative modulator inhibiting both receptors, with comparable functional affinity. Compounds 7a, 7g, 9c, 9e, and 13e were identified as potent negative modulators of CXCR4, while 13a acted as a modest positive modulator, and 6a, 6b, and 11a as weak allosteric agonists on CXCR4. The research provides valuable insights into the structure-activity relationship of these ligands and offers promising candidates for the development of selective or dual modulators of chemokine receptors, which could have significant potential in treating diseases such as inflammation, autoimmune disorders, and cancer.

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