3-Amino-2-hydroxy-N,N-dimethylbenzamide Hydrochloride

Base Information

• Chemical Name: 3-Amino-2-hydroxy-N,N-dimethylbenzamide Hydrochloride
• CAS No.: 1000993-70-3
• Molecular Formula: C9H13ClN2O2
• Molecular Weight: 216.667
• Hs Code.: 2924299090
• Mol file: 1000993-70-3.mol

Synonyms:2-hydroxy-N,N-dimethyl-3-amino-benzamide hydrochloride;Ethanol,N-oxide;Nifuratrone;

Chemical Property of 3-Amino-2-hydroxy-N,N-dimethylbenzamide Hydrochloride

Chemical Property:

• PSA: 66.56000
• LogP: 2.05940

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Amino-2-hydroxy-N,N-dimethylbenzamide hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Amino-2-hydroxy-N,N-dimethylbenzamide Hydrochloride

There total 2 articles about 3-Amino-2-hydroxy-N,N-dimethylbenzamide Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-bromo-2-hydroxy-3-nitro-N,N-dimethylbenzamide (473731-67-8) → 2-hydroxy-N,N-dimethyl-3-amino-benzamide hydrochloride (1000993-70-3)

Guidance literature:

5-bromo-2-hydroxy-3-nitro-N,N-dimethylbenzamide; With potassium ethoxide; hydrogen; 5%-palladium/activated carbon; In ethanol; for 6h; under 6205.94 - 7757.43 Torr;

With hydrogenchloride; In water;

Reference yield:

3-amino-2-hydroxy-N,N-dimethylbenzamide (464913-11-9) → 2-hydroxy-N,N-dimethyl-3-amino-benzamide hydrochloride (1000993-70-3)

Guidance literature:

With hydrogenchloride; In methyl t-butylether; ethanol; water; at 0 ℃; Product distribution / selectivity;

Reference yield: 88.0%

2-hydroxy-N,N-dimethyl-3-amino-benzamide hydrochloride (1000993-70-3) + 3,4-dimethoxy-3-cyclobutene-1,2-dione (5222-73-1) → 2-hydroxy-3-(2-methoxy-3,4-dioxo-cyclobut-1-enylamino)-N,N-dimethyl-benzamide (473732-10-4)

Guidance literature:

2-hydroxy-N,N-dimethyl-3-amino-benzamide hydrochloride; 3,4-dimethoxy-3-cyclobutene-1,2-dione; In methanol; at -5 - 5 ℃; for 5h;

With triethylamine; In methanol; at -5 - 5 ℃; for 1h;

With acetic acid; In methanol; at -5 - 5 ℃; for 0.25h; Product distribution / selectivity; Heating / reflux;

upstream raw materials:

5-bromo-2-hydroxy-3-nitro-N,N-dimethylbenzamide

3-amino-2-hydroxy-N,N-dimethylbenzamide

Downstream raw materials:

2-hydroxy-3-(2-methoxy-3,4-dioxo-cyclobut-1-enylamino)-N,N-dimethyl-benzamide

3-((2-ethoxy-3,4-dioxocyclobut-1-en-1-yl)amino)-2-hydroxy-N,N-dimethylbenzamide

Refernces

• 1、 -. "PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 1,2-SUBSTITUTED 3,4-DIOXO-1-CYCLOBUTENE COMPOUNDS". Page/Page column 35-36. . Retrieved 2009/03/07.