IMidazo[1,2-a]pyridine-2-carboxylic acid, 8-broMo-, ethyl ester

Base Information

• Chemical Name: IMidazo[1,2-a]pyridine-2-carboxylic acid, 8-broMo-, ethyl ester
• CAS No.: 1038393-19-9
• Molecular Formula: C10H9BrN2O2
• Molecular Weight: 269.09
• Mol file: 1038393-19-9.mol

Synonyms:8-BROMO-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER;ETHYL 8-BROMOH-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLATE;IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID,8-BROMO-,ETHYL ESTER;

Chemical Property of IMidazo[1,2-a]pyridine-2-carboxylic acid, 8-broMo-, ethyl ester

Chemical Property:

• PKA: 0.33±0.50(Predicted)
• PSA: 43.60000
• Density: 1.60±0.1 g/cm3(Predicted)
• LogP: 2.27350

Purity/Quality:

NLT 98% ^*data from raw suppliers

Ethyl 8-bromoimidazo[1,2-a]pyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of IMidazo[1,2-a]pyridine-2-carboxylic acid, 8-broMo-, ethyl ester

There total 1 articles about IMidazo[1,2-a]pyridine-2-carboxylic acid, 8-broMo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-Amino-3-bromopyridine (13534-99-1) + ethyl Bromopyruvate (70-23-5) → ethyl 8-bromoimidazo[1,2-a]pyridine-2-carboxylate (1038393-19-9)

Guidance literature:

2-Amino-3-bromopyridine; ethyl Bromopyruvate; In ethanol; for 60h; Reflux;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield: 88.0%

ethyl 8-bromoimidazo[1,2-a]pyridine-2-carboxylate (1038393-19-9) → 8-bromo-imidazo(1,2-a)pyridine-2-carboxylic acid (1026201-45-5)

Guidance literature:

ethyl 8-bromoimidazo[1,2-a]pyridine-2-carboxylate; With water; lithium hydroxide; In 1,4-dioxane; at 20 ℃; for 20h;

With hydrogenchloride; In water; pH=4;

Reference yield: 46.0%

ethyl 8-bromoimidazo[1,2-a]pyridine-2-carboxylate (1038393-19-9) + α-bromo-α,α-difluoro-acetophenone (1610-04-4) → ethyl 8-bromo-3-(1,1-difluoro-2-oxo-2-phenylethyl)imidazo[1,2-a]pyridine-2-carboxylate

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; In acetonitrile; at 20 ℃; for 72h; Inert atmosphere; Schlenk technique; Irradiation; Sealed tube;

DOI:10.1021/acs.orglett.9b02487

upstream raw materials:

2-Amino-3-bromopyridine

ethyl Bromopyruvate

Downstream raw materials:

8-bromo-imidazo(1,2-a)pyridine-2-carboxylic acid

Refernces

• 1、 -. "SUBSTITUTED BICYCLIC IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS". Page/Page column 57. . Retrieved 2010/08/05.