Ambroxol

Base Information

Chemical Name:Ambroxol
CAS No.:107814-37-9
Molecular Formula:C13H18Br2N2O
Molecular Weight:378.10282
Hs Code.:
European Community (EC) Number:242-500-3
UNII:200168S0CL,QH6ZT6J071
DSSTox Substance ID:DTXSID8022583,DTXSID60860228
Nikkaji Number:J13.659J,J3.274.453B
Wikipedia:Ambroxol
Wikidata:Q221637,Q105124245
NCI Thesaurus Code:C74262
RXCUI:625
Pharos Ligand ID:A3KGNKUQTWCV
ChEMBL ID:CHEMBL153479,CHEMBL1477775
Mol file:107814-37-9.mol

Synonyms:4-(((2-Amino-3,5-dibromophenyl)methyl)amino)cyclohexanol;Abrohexal;AM, Bisolvon;Ambril;Ambro Puren;Ambro-Puren;Ambrobeta;Ambrofur;Ambrohexal;Ambrol?s;Ambrolitic;AMBROPP;AmbroPuren;Ambroten;Ambroxin;Ambroxocompren;Ambroxol;Bisolvon AM;Bromhexine Metabolite VIII;Bronchopront;Bronchowern;Broxol;Contac Husten Trunk;Contac Husten-Trunk;Contac HustenTrunk;Dinobroxol;Duramucal;Ebromin;Expeflen;Expit;Farmabroxol;Flavamed;Frenopect;Gelopol;Hustenl?ser, Pect;Hustenl?ser, Therapin;Larylin Husten L?ser;Larylin Husten-L?ser;Larylin HustenL?ser;Lasolvan;Metabolite VIII, Bromhexine;Mibrox;Motosol;Muco Fips;Muco-Fips;MucoFips;Mucosolvan;Mucotablin;NA 872;NA-872;NA872;P?diamuc;Pect Hustenl?ser;Pulmonal S;Pulmonal, Ringelheimer;Ringelheimer Pulmonal;Sekretovit;stas Hustenl?ser;stas-Hustenl?ser;stasHustenl?ser;Surbronc;Therapin Hustenl?ser

Suppliers and Price of Ambroxol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
CIS-4-[2-AMINO,3,5-DIBROMOBENZYL)AMINO]CYCLOHEXANOL 95.00%
5MG
$ 498.85

AvaChem
Cis-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohexanol Hydrochloride
50mg
$ 375.00

AvaChem
Cis-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohexanol Hydrochloride
10mg
$ 155.00

Crysdot
cis-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol 97%
1g
$ 470.00

Medical Isotopes, Inc.
rac-cis-Ambroxol
10 mg
$ 675.00

TRC
rac-cis-Ambroxol
100mg
$ 1620.00

TRC
rac-cis-Ambroxol
10mg
$ 205.00

Alichem
cis-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol
250mg
$ 215.82

Total 22 raw suppliers

Chemical Property of Ambroxol

Chemical Property:

Boiling Point:468.6±45.0 °C(Predicted)
PKA:15.12±0.40(Predicted)
PSA：58.28000
Density:1.70±0.1 g/cm3(Predicted)
LogP:4.15900
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:2.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:377.97654
Heavy Atom Count:18
Complexity:259

Purity/Quality:

99%, ^*data from raw suppliers

CIS-4-[2-AMINO,3,5-DIBROMOBENZYL)AMINO]CYCLOHEXANOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(CCC1NCC2=C(C(=CC(=C2)Br)Br)N)O
Recent ClinicalTrials:A Double-blind Randomised, Placebo-controlled Clinical Trial to Test Ambroxol Treatment in ALS
Recent EU Clinical Trials:Ambroxol inhalation for mucus clearance in palliative care patients - a randomized placebo-controlled double-blind pilot study.
Recent NIPH Clinical Trials:Japan-Ambroxol Chaperone Study
Uses cis-Ambroxol is the cis-isomeric impurity of Ambroxol (A575905). cis-Ambroxol is a metabolite Bromhexine (B678600).

Technology Process of Ambroxol

There total 20 articles about Ambroxol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.9%