(2-Fluoro-4-methoxyphenyl)methanamine hydrochloride

Base Information

• Chemical Name: (2-Fluoro-4-methoxyphenyl)methanamine hydrochloride
• CAS No.: 937783-85-2
• Molecular Formula: C₈H₁₀FNO*ClH
• Molecular Weight: 191.633
• European Community (EC) Number: 844-277-3
• DSSTox Substance ID: DTXSID90700744
• Mol file: 937783-85-2.mol

Synonyms:(2-Fluoro-4-methoxyphenyl)methanamine hydrochloride;937783-85-2;2-FLUORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE;2-fluoro-4-methoxy benzylamine hcl;(2-fluoro-4-methoxyphenyl)methanamine;hydrochloride;(2-Fluoro-4-methoxyphenyl)methanaminehydrochloride;SCHEMBL20767083;DTXSID90700744;CK2394;MFCD04116339;AKOS015995493;AS-45897;(2-Fluoro-4-methoxyphenyl)methanamine HCl;CS-0131607;FT-0709437;EN300-106409;A1-12484;Z1416282396;1-(2-FLUORO-4-METHOXYPHENYL)METHANAMINE HYDROCHLORIDE;1-(2-Fluoro-4-methoxyphenyl)methanamine--hydrogen chloride (1/1)

Chemical Property of (2-Fluoro-4-methoxyphenyl)methanamine hydrochloride

Chemical Property:

• PSA: 35.25000
• LogP: 2.79530
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 191.0513198
• Heavy Atom Count: 12
• Complexity: 121

Purity/Quality:

98%min ^*data from raw suppliers

2-Fluoro-4-methoxybenzylaminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)CN)F.Cl

Technology Process of (2-Fluoro-4-methoxyphenyl)methanamine hydrochloride

There total 3 articles about (2-Fluoro-4-methoxyphenyl)methanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

di-tert-butyl [2-fluoro-4-methoxybenzylamino]dicarboxylate (937783-84-1) → (2-fluoro-4-methoxyphenyl)methanamine hydrochloride (937783-85-2)

Guidance literature:

With hydrogenchloride; In methanol; diethyl ether; at 20 ℃; for 5h;

DOI:10.1016/j.bcp.2007.01.026

Reference yield:

2-fluoro-4-methoxy-benzaldehyde (331-64-6) → (2-fluoro-4-methoxyphenyl)methanamine hydrochloride (937783-85-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 96 percent / NaBH₄ / methanol / 3.5 h / 0 - 20 °C

2.1: carbon tetrabromide; triphenylphosphine / CH₂Cl₂ / 3 h / 20 °C

2.2: 55 percent / sodium hydride / tetrahydrofuran / 8 h / 0 - 20 °C

3.1: 86 percent / HCl / methanol; diethyl ether / 5 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; carbon tetrabromide; triphenylphosphine; In methanol; diethyl ether; dichloromethane;

DOI:10.1016/j.bcp.2007.01.026

Reference yield:

(2-fluoro-4-methoxyphenyl)methanol (405-09-4) → (2-fluoro-4-methoxyphenyl)methanamine hydrochloride (937783-85-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: carbon tetrabromide; triphenylphosphine / CH₂Cl₂ / 3 h / 20 °C

1.2: 55 percent / sodium hydride / tetrahydrofuran / 8 h / 0 - 20 °C

2.1: 86 percent / HCl / methanol; diethyl ether / 5 h / 20 °C

With hydrogenchloride; carbon tetrabromide; triphenylphosphine; In methanol; diethyl ether; dichloromethane;

DOI:10.1016/j.bcp.2007.01.026

upstream raw materials:

di-tert-butyl [2-fluoro-4-methoxybenzylamino]dicarboxylate

2-fluoro-4-methoxy-benzaldehyde

(2-fluoro-4-methoxyphenyl)methanol

Refernces