3-amino-5-bromopyridine-2-carboxylic acid

Base Information

• Chemical Name: 3-amino-5-bromopyridine-2-carboxylic acid
• CAS No.: 870997-85-6
• Molecular Formula: C6H5BrN2O2
• Molecular Weight: 217.022
• Hs Code.: 2933399090
• Mol file: 870997-85-6.mol

Synonyms:3-amino-5-bromopyridine-2-carboxylic acid;3-Amino-5-bromopyridine-2...;3-Amino-5-bromopicolinic acid;3-AMino-5-broMopyridin-2-carboxylic acid;3-AMino-5-broMopyridine-2-carboxylic;2-Pyridinecarboxylic acid, 3-aMino-5-broMo-

Chemical Property of 3-amino-5-bromopyridine-2-carboxylic acid

Chemical Property:

• Boiling Point: 399.0±42.0 °C(Predicted)
• PKA: 4.15±0.10(Predicted)
• PSA: 76.21000
• Density: 1.909±0.06 g/cm3(Predicted)
• LogP: 1.70570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

3-Amino-5-bromopyridine-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-amino-5-bromopyridine-2-carboxylic acid

There total 2 articles about 3-amino-5-bromopyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-amino-5-bromopyridine-2-carboxylic acid amide (669066-89-1) → 3-amino-5-bromo-pyridine-2-carboxylic acid (870997-85-6)

Guidance literature:

3-amino-5-bromopyridine-2-carboxylic acid amide; With sodium hydroxide; In water; for 5h; Reflux;

With hydrogenchloride; at 0 ℃; pH=7;

Reference yield:

5-bromo-3-nitropyridine-2-carbonitrile (573675-25-9) → 3-amino-5-bromo-pyridine-2-carboxylic acid (870997-85-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 3-amino-5-bromo-pyridine-2-carboxylic acid / Raney Nickel / ethanol / 14 h / 20 °C

2.1: sodium hydroxide / water / 5 h / Reflux

2.2: 0 °C / pH 7

With 3-amino-5-bromo-pyridine-2-carboxylic acid; sodium hydroxide; Raney Nickel; In ethanol; water;

Reference yield: 90.0%

4-Fluorothiophenol (371-42-6) + 3-amino-5-bromo-pyridine-2-carboxylic acid (870997-85-6) → 3-amino-5-(4-fluorophenylsulfanyl)pyridine-2-carboxylic acid

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 100 ℃; for 5h;

upstream raw materials:

3-amino-5-bromopyridine-2-carboxylic acid amide

5-bromo-3-nitropyridine-2-carbonitrile

Downstream raw materials:

7-bromopyrido[3,2-d]pyrimidine-2,4-diol

7-bromo-2,4-dichloropyrido[3,2-d]pyrimidine

C₂₉H₂₉Cl₃N₈O₅

3-amino-5-bromopyridine-2-carboxylic acid amide