4-Amino-1-Boc-2-methylpiperidine

Base Information

• Chemical Name: 4-Amino-1-Boc-2-methylpiperidine
• CAS No.: 952182-04-6
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.308
• Hs Code.: 2933399090
• Mol file: 952182-04-6.mol

Synonyms:tert-butyl 4-amino-2-methylpiperidine-1-carboxylate;

Chemical Property of 4-Amino-1-Boc-2-methylpiperidine

Chemical Property:

• PSA: 55.56000
• LogP: 2.37130
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

tert-butyl4-amino-2-methylpiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Amino-1-Boc-2-methylpiperidine

There total 1 articles about 4-Amino-1-Boc-2-methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 2-methyl-4-oxopiperidine-1-carboxylate (190906-92-4) → tert-butyl 4-amino-2-methylpiperidine-1-carboxylate (952182-04-6,1691250-97-1,1434073-26-3)

Guidance literature:

With palladium 10% on activated carbon; ammonia; hydrogen; In methanol; for 60h; under 2585.81 Torr;

Reference yield: 56.8%

tert-butyl 4-amino-2-methylpiperidine-1-carboxylate (952182-04-6,1691250-97-1,1434073-26-3) + 2-chloro-3-(4-fluorobenzyl)pyrazine → tert-butyl 4-((3-(4-fluorobenzyl)pyrazin-2-yl)amino)-2-methylpiperidine-1-carboxylate

Guidance literature:

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100 ℃; for 16h; under 760.051 Torr; Inert atmosphere;

Reference yield:

tert-butyl 4-amino-2-methylpiperidine-1-carboxylate (952182-04-6,1691250-97-1,1434073-26-3) + ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → tert-butyl 2-methyl-4-((2-nitrophenyl)amino)piperidine-1-carboxylate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 80 ℃; for 16h; Cooling with ice;

upstream raw materials:

tert-butyl 2-methyl-4-oxopiperidine-1-carboxylate

Refernces