6ALPHA, 7ALPHA-EPOXY-2-OXABICYCLO[3.3.0]OCTAN-3-ONE

Base Information

• Chemical Name: 6ALPHA, 7ALPHA-EPOXY-2-OXABICYCLO[3.3.0]OCTAN-3-ONE
• CAS No.: 26115-01-5
• Molecular Formula: C7H8O3
• Molecular Weight: 138.16400
• Mol file: 26115-01-5.mol

Synonyms:6a,7a-epoxy-2-oxabicyclo[3.3]octan-3-one;6α,7α-Epoxy-2-oxabicyclo[3.3.0]octan-3-one;6A, 7A-EPOXY-2-OXABICYCLO[3.3]OCTAN-3-ONE 98+%;6ALPHA, 7ALPHA-EPOXY-2-OXABICYCLO[3.3.0]OCTAN-3-ONE;4H-Oxireno[3,4]cyclopenta[1,2-b]furan-4-one, hexahydro-, (1a...;(1aR,5bS)-hexahydro-4H-oxireno[2',3':3,4]cyclopenta[1,2-b]furan-4-one;4H-Oxireno[3,4]cyclopenta[1,2-b]furan-4-one, hexahydro-, (1aa,2aa,5aa,5ba)-;4H-Oxireno[3,4]cyclopenta[1,2-b]furan-4-one, hexahydro-, (1aR,2aS,5aS,5bS)-rel-;rel-(1aR,2aS,5aS,5bS)-Hexahydro-4H-oxireno[2',3':3,4]cyclopenta[1,2-b]furan-4-one;(1aR,2aS,5aS,5bS)-tetrahydro-1aH-oxireno[2',3':3,4]cyclopenta[1,2-b]furan-4(5bH)-one

Chemical Property of 6ALPHA, 7ALPHA-EPOXY-2-OXABICYCLO[3.3.0]OCTAN-3-ONE

Chemical Property:

• Boiling Point: 325.7±42.0 °C(Predicted)
• PSA: 29.60000
• Density: 1.397±0.06 g/cm3(Predicted)
• LogP: 0.75280

Purity/Quality:

97% ^*data from raw suppliers

6ALPHA, 7ALPHA-EPOXY-2-OXABICYCLO[3.3]OCTAN-3-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6ALPHA, 7ALPHA-EPOXY-2-OXABICYCLO[3.3.0]OCTAN-3-ONE

There total 53 articles about 6ALPHA, 7ALPHA-EPOXY-2-OXABICYCLO[3.3.0]OCTAN-3-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1S,5S)-6-exo,7-endo-dihydroxy-3-oxo-2-oxabicyclo<3.3.0>octane (80734-99-2) → (1S,2R,4S,6S)-8-oxo-3,7-dioxatricyclo<4.3.0.02,4>nonane (80735-00-8,26115-01-5)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; at 70 ℃; for 0.166667h;

Reference yield: 88.0%

(1R,5S)-2-oxabicyclo[3.3.0]oct-6-en-3-one (34638-25-0,38110-77-9,43119-28-4,54483-22-6,26054-46-6) → (1aS,2aR,5aR,5bR)-hexahydro-4H-oxireno[3,4]cyclopenta[1,2-b]furan-4-one (54483-30-6,26115-01-5)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 10 - 20 ℃; for 4h;

Reference yield: 60.0%

(1aR,2aS,5aS,5bS)-5,5-dichlorohexahydro-4H-oxireno[3,4]cyclopenta[1,2-b]furan-4-one → (1S,2S,4R,6S)-8-oxo-3,7-dioxatricyclo<4.3.0.02,4>nonane (59829-44-6,26115-01-5)

Guidance literature:

With zinc copper; ammonium chloride; In methanol; at 64 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.tetlet.2015.10.106

upstream raw materials:

(-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one

(1R,5S)-bicyclo[3.2.0]hept-2-en-6-one

(1S,5S)-6-exo,7-endo-dihydroxy-3-oxo-2-oxabicyclo<3.3.0>octane

C₂₁H₁₇NO₄