methyl 5-(3-chloro-2-fluorobenzyl)-2-fluoro-4-methoxybenzoate

Base Information

• Chemical Name: methyl 5-(3-chloro-2-fluorobenzyl)-2-fluoro-4-methoxybenzoate
• CAS No.: 949465-76-3
• Molecular Formula: C16H13ClF2O3
• Molecular Weight: 326.727
• Mol file: 949465-76-3.mol

Synonyms:Methyl 5-(3-chloro-2-fluorobenzyl)-2-fluoro-4-Methoxybenzoate;5-(3-chloro-2-fluorobenzyl)-2-fluoro-4-methoxybenzoic acid methyl ester

Chemical Property of methyl 5-(3-chloro-2-fluorobenzyl)-2-fluoro-4-methoxybenzoate

Chemical Property:

• PSA: 35.53000
• LogP: 4.00420

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 5-(3-chloro-2-fluorobenzyl)-2-fluoro-4-methoxybenzoate

There total 1 articles about methyl 5-(3-chloro-2-fluorobenzyl)-2-fluoro-4-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.4%

3-chloro-2-fluorobenzyl zinc bromide (869893-91-4) + 5-methyl 5-bromo-2-fluoro-4-methoxybenzoate (949465-86-5) → 5-(3-chloro-2-fluorobenzyl)-2-fluoro-4-methoxybenzoic acid methyl ester (949465-76-3)

Guidance literature:

tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 20 - 85 ℃; for 2h;

Reference yield: 93.4%

5-(3-chloro-2-fluorobenzyl)-2-fluoro-4-methoxybenzoic acid methyl ester (949465-76-3) → 5-(3-chloro-2-fluorobenzyl)-2-fluoro-4-methoxybenzoic acid (949465-87-6)

Guidance literature:

5-(3-chloro-2-fluorobenzyl)-2-fluoro-4-methoxybenzoic acid methyl ester; With sodium hydroxide; water; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 3.5h;

With hydrogenchloride; water; In 1-methyl-pyrrolidin-2-one; at 20 ℃;

upstream raw materials:

3-chloro-2-fluorobenzyl zinc bromide

5-methyl 5-bromo-2-fluoro-4-methoxybenzoate

Downstream raw materials:

5-(3-chloro-2-fluorobenzyl)-2-fluoro-4-methoxybenzoic acid