6-dimethylamino-4-methyl-pyridineboronic acid

Base Information

• Chemical Name: 6-dimethylamino-4-methyl-pyridineboronic acid
• CAS No.: 535934-70-4
• Molecular Formula: C8H13BN2O2
• Molecular Weight: 180.014
• Hs Code.: 2933399990
• Mol file: 535934-70-4.mol

Synonyms:[6-(Dimethylamino)pyridin-3-yl]boronic acid dihydrochloride

Chemical Property of 6-dimethylamino-4-methyl-pyridineboronic acid

Chemical Property:

• Vapor Pressure: 2.95E-07mmHg at 25°C
• Boiling Point: 404.1°C at 760 mmHg
• PKA: 4.28±0.58(Predicted)
• Flash Point: 198.2°C
• PSA: 56.59000
• Density: 1.15±0.1 g/cm3(Predicted)
• LogP: -1.17260
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

[6-(Dimethylamino)-4-methyl-3-pyridinyl]-boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: [6-(Dimethylamino)-4-methyl-3-pyridinyl]-boronic acid

Technology Process of 6-dimethylamino-4-methyl-pyridineboronic acid

There total 1 articles about 6-dimethylamino-4-methyl-pyridineboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H25BN2O2 → [6-(dimethylamino)-4-mefhylpyridin-3-yl]boronic acid (535934-70-4)

Guidance literature:

With water; acetic acid; In tetrahydrofuran; hexane; Inert atmosphere;

DOI:10.1021/jm900025h

Reference yield: 39.0%

[6-(dimethylamino)-4-mefhylpyridin-3-yl]boronic acid (535934-70-4) + benzyl (3R,4S)-3-[(3,6-diethyl-5-iodopyrazin-2-yl)amino]-4-ethoxypyrrolidine-1-carboxylate (793675-88-4) → benzyl (3R,4S)-3-({5-[6-(dimethylamino)-4-methylpyridin-3-yl]-3,6-diethylpyrazin-2-yl}amino)-4-ethoxypyrrolidine-1-carboxylate (793675-89-5)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 80 ℃; for 18h;

Reference yield:

[6-(dimethylamino)-4-mefhylpyridin-3-yl]boronic acid (535934-70-4) + C19H23BrN4O3 (1435972-38-5) → C27H34N6O3 (1435972-25-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In N,N-dimethyl-formamide; at 120 - 150 ℃; Microwave irradiation;

DOI:10.1016/j.bmcl.2013.03.082

Downstream raw materials:

benzyl (3R,4S)-3-({5-[6-(dimethylamino)-4-methylpyridin-3-yl]-3,6-diethylpyrazin-2-yl}amino)-4-ethoxypyrrolidine-1-carboxylate

C₂₇H₃₄N₆O₃