3-Iodo-2,6-dimethylaniline

Base Information

• Chemical Name: 3-Iodo-2,6-dimethylaniline
• CAS No.: 784107-79-5
• Molecular Formula: C₈H₁₀IN
• Molecular Weight: 247.079
• Mol file: 784107-79-5.mol

Synonyms:3-iodo-2,6-diMethylaniline;3-Iodo-2,6-dimethylbenzenamine;3-Iodo-2,6-dimethyl-phenylamine;Benzenamine, 3-iodo-2,6-dimethyl-

Chemical Property of 3-Iodo-2,6-dimethylaniline

Chemical Property:

• Boiling Point: 296.2±28.0 °C(Predicted)
• PKA: 3.34±0.10(Predicted)
• PSA: 26.02000
• Density: 1.688±0.06 g/cm3(Predicted)
• LogP: 3.07140
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

≥95% ^*data from raw suppliers

3-Iodo-2,6-dimethyl-phenylamine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Iodo-2,6-dimethylaniline

There total 2 articles about 3-Iodo-2,6-dimethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-iodo-2,4-dimethyl-3-nitro-benzene (56404-21-8) → 3-iodo-2,6-dimethylaniline (784107-79-5)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; Reflux;

Reference yield:

2,6-dimethylnitrobenzene (81-20-9) → 3-iodo-2,6-dimethylaniline (784107-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / iodine; aq. periodic acid; acetic acid / H₂SO₄ / 96 h / 90 °C

2: Fe; aq. sulfuric acid / 48 h / Heating

With sulfuric acid; iodine; iron; acetic acid; periodic acid; sulfuric acid;

DOI:10.1248/cpb.52.1445

upstream raw materials:

1-iodo-2,4-dimethyl-3-nitro-benzene

2,6-dimethylnitrobenzene

Refernces

• 1、 Morimoto, Toshiaki,Yoshikawa, Kiyoshi,Murata, Masanao,Yamamoto, Naoko,Achiwa, Kazuo. "Preparation of axially chiral biphenyl diphosphine ligands and their application in asymmetric hydrogenation". . p. 1445 - 1450. Retrieved 2007/10/03.