Technology Process of 3-Methyl-pyrrolidine-3-carboxylic acid
There total 6 articles about 3-Methyl-pyrrolidine-3-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 20 ℃;
for 1h;
DOI:10.1021/jo4010316
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium tetrahydroborate; cobalt(II) chloride / methanol / 24 h / 0 - 20 °C / Inert atmosphere
1.2: 3 h / Inert atmosphere
2.1: Lawessons reagent / tetrahydrofuran / 17 h / 20 °C / Inert atmosphere
3.1: hydrogen / water; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
4.1: sodium hydroxide / water / 16 h / 20 °C / pH 8 - 10
5.1: trifluoroacetic acid / dichloromethane / 17 h / 20 °C
6.1: hydrogen; palladium 10% on activated carbon / methanol / 1 h / 20 °C
With
Lawessons reagent; sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; cobalt(II) chloride; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo4010316
- Guidance literature:
-
Multi-step reaction with 5 steps
1: Lawessons reagent / tetrahydrofuran / 17 h / 20 °C / Inert atmosphere
2: hydrogen / water; tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
3: sodium hydroxide / water / 16 h / 20 °C / pH 8 - 10
4: trifluoroacetic acid / dichloromethane / 17 h / 20 °C
5: hydrogen; palladium 10% on activated carbon / methanol / 1 h / 20 °C
With
Lawessons reagent; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo4010316
