5,6-Dimethoxypicolinonitrile

Base Information

• Chemical Name: 5,6-Dimethoxypicolinonitrile
• CAS No.: 1112851-50-9
• Molecular Formula: C8H8N2O2
• Molecular Weight: 164.160995
• Hs Code.: 2933399090
• Mol file: 1112851-50-9.mol

Synonyms:5,6-dimethoxypyridine-2-carbonitrile

Chemical Property of 5,6-Dimethoxypicolinonitrile

Chemical Property:

• Boiling Point: 275.4±40.0 °C(Predicted)
• PKA: -4.13±0.10(Predicted)
• PSA: 55.14000
• Density: 1.19±0.1 g/cm3(Predicted)
• LogP: 0.97048

Purity/Quality:

98%min ^*data from raw suppliers

5,6-Dimethoxypicolinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

Useful:

Technology Process of 5,6-Dimethoxypicolinonitrile

There total 1 articles about 5,6-Dimethoxypicolinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

copper(l) cyanide + 2,3-dimethoxy-6-iodo-pyridine (321535-23-3,1138444-04-8) → 5,6-dimethoxypyridine-2-carbonitrile (1112851-50-9)

Guidance literature:

In N,N-dimethyl-formamide; at 150 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation;

DOI:10.1002/cmdc.201300447

Reference yield: 94.0%

5,6-dimethoxypyridine-2-carbonitrile (1112851-50-9) → (5,6-dimethoxypyridin-2-yl)methanamine (1112850-40-4)

Guidance literature:

With hydrogenchloride; 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol; water; at 25 ℃; for 1.5h;

DOI:10.1002/cmdc.201300447

upstream raw materials:

2,3-dimethoxy-6-iodo-pyridine

Downstream raw materials:

(5,6-dimethoxypyridin-2-yl)methanamine

Refernces

• 1、 -. "TRIPYRIDYL CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS". Page/Page column 17-18. . Retrieved 2010/03/02.
• 2、 -. "PYRIDAZINE CARBOXAMIDE OREXIN RECEPTOR ANTAGONISTS". Page/Page column 45-46. . Retrieved 2010/05/14.