tert-butyl 1-(3-broMophenyl)ethylcarbaMate

Base Information

• Chemical Name: tert-butyl 1-(3-broMophenyl)ethylcarbaMate
• CAS No.: 375853-98-8
• Molecular Formula: C13H18BrNO2
• Molecular Weight: 300.195
• Hs Code.: 2924299090
• Mol file: 375853-98-8.mol

Synonyms:tert-butyl 1-(3-broMophenyl)ethylcarbaMate;CarbaMic acid, [1-(3-broMophenyl)ethyl]-, 1,1-diMethylethyl ester

Chemical Property of tert-butyl 1-(3-broMophenyl)ethylcarbaMate

Chemical Property:

• Boiling Point: 375.5±25.0 °C(Predicted)
• PKA: 12.02±0.46(Predicted)
• PSA: 41.82000
• Density: 1.282±0.06 g/cm3(Predicted)
• LogP: 4.23920
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

N-BOC-1-(3-bromophenyl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 1-(3-broMophenyl)ethylcarbaMate

There total 3 articles about tert-butyl 1-(3-broMophenyl)ethylcarbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + 1-(3-bromophenyl)ethanamine (74877-08-0) → [1-(3-bromophenyl)ethyl]-carbamic acid tert-butyl ester (375853-98-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 20h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + N-[1-(3-bromophenyl)ethylidene]hydroxyl amine (24280-05-5) → [1-(3-bromophenyl)ethyl]-carbamic acid tert-butyl ester (375853-98-8)

Guidance literature:

With triethylamine; In N-methyl-acetamide; acetic acid; N,N-dimethyl-formamide;

Reference yield:

1-(3-Bromophenyl)ethanone (2142-63-4) → [1-(3-bromophenyl)ethyl]-carbamic acid tert-butyl ester (375853-98-8)

Guidance literature:

Multi-step reaction with 2 steps

1: formic acid; formamide / 170 °C

2: dichloromethane / 20 °C

With formic acid; formamide; In dichloromethane;

upstream raw materials:

di-tert-butyl dicarbonate

1-(3-bromophenyl)ethanamine

N-[1-(3-bromophenyl)ethylidene]hydroxyl amine

1-(3-Bromophenyl)ethanone

Downstream raw materials:

C₁₉H₂₉NO₄

C₁₅H₂₁NO₄

C₃₃H₃₉N₇O₄S

C₂₈H₃₁N₇O₂S

Refernces

• 1、 -. "INHIBITORS OF KINASE ACTIVITY". Page/Page column 96. . Retrieved 2008/12/05.
• 2、 -. "Chemical compounds". . . Retrieved 2008/06/13.