Pentanoic acid, 4,5-diamino-5-oxo-, phenylmethyl ester, monohydrochloride, (R)-

Base Information

• Chemical Name: Pentanoic acid, 4,5-diamino-5-oxo-, phenylmethyl ester, monohydrochloride, (R)-
• CAS No.: 18800-75-4
• Molecular Formula: C12H16N2O3.ClH
• Molecular Weight: 272.72798
• Hs Code.: 2924299090
• Mol file: 18800-75-4.mol

Synonyms:D-Glu(OBzl)-NH2·HCl;D-Isoglutamine benzyl ester monochlorohydrate;D-Glutamic acid γ-benzyl ester α-amide hydrochloride;benzyl (4R)-4-amino-4-carbamoylbutanoate hydrochloride;D-Glutamic acid γ-benzyl ester α-amide hydrochloride≥ 99% (HPLC);Pentanoic acid, 4,5-diaMino-5-oxo-, phenylMethyl ester, Monohydrochloride, (R)-;Pentanoic acid, 4,5-diamino-5-oxo-, phenylmethyl ester, hydrochloride (1:1), (4R)-

Chemical Property of Pentanoic acid, 4,5-diamino-5-oxo-, phenylmethyl ester, monohydrochloride, (R)-

Chemical Property:

• PSA: 95.41000
• LogP: 2.52520

Purity/Quality:

99% ^*data from raw suppliers

D-IsoglutamineBenzylEsterHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: D-Isoglutamine Benzyl Ester Hydrochloride is an intermediate for Mifamurtide (M343940). Mifamurtide is used in the treatment of osteosarcoma and increases survival of nonmetastatic and metastatic patients undergoing chemotherapy for osteosarcoma.

Technology Process of Pentanoic acid, 4,5-diamino-5-oxo-, phenylmethyl ester, monohydrochloride, (R)-

There total 3 articles about Pentanoic acid, 4,5-diamino-5-oxo-, phenylmethyl ester, monohydrochloride, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl N-tert-butyloxycarbonyl-L-γ-glutamate α-amide (18800-73-2) → Glu(OBn)-NH2 hydrochloride (18800-75-4,63091-89-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 0.75h;

DOI:10.1021/jm980612i

Reference yield:

Boc-Glu(OBzl)-OH (13574-13-5) → Glu(OBn)-NH2 hydrochloride (18800-75-4,63091-89-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) benzotriazol-1-yl-1,1,3,3-tetramethyluronium tetrafluoroborate, N-methylmorpholine, 2.) NH₃, N-methylmorpholine / 1.) CH₃CN, 5 min, 2.) CH₃CN, RT

2: 4N aq. HCl / dioxane / 0.75 h

With 4-methyl-morpholine; hydrogenchloride; ammonia; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In 1,4-dioxane;

DOI:10.1021/jm980612i

Reference yield:

→ D-γ-methyl isoglutamine hydrochloride (18800-75-4,63091-89-4)

Guidance literature:

upstream raw materials:

benzyl N-tert-butyloxycarbonyl-L-γ-glutamate α-amide

Boc-Glu(OBzl)-OH

Downstream raw materials:

tert-butoxycarbonyl-L-alanyl-D-isoglutamine benzyl ester

Benzyl-t.-butyloxycarbonyl-L-Alanyl-D-isoglutaminat