benzyl 3-(hydroxyMethyl)cyclobutanecarboxylate

Base Information

• Chemical Name: benzyl 3-(hydroxyMethyl)cyclobutanecarboxylate
• CAS No.: 939768-59-9
• Molecular Formula: C₁₃H₁₆O₃
• Molecular Weight: 220.268
• Hs Code.: 2918990090
• Mol file: 939768-59-9.mol

Synonyms:3-((Benzyloxy)methyl)cyclobutanecarboxylic acid; Benzyl 3-hydroxyMethyl cyclobutanecarboxylic acid

Chemical Property of benzyl 3-(hydroxyMethyl)cyclobutanecarboxylate

Chemical Property:

• Boiling Point: 339.6±15.0 °C(Predicted)
• PKA: 15.05±0.10(Predicted)
• PSA: 46.53000
• Density: 1.172±0.06 g/cm3(Predicted)
• LogP: 2.31400
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Benzyl3-(Hydroxymethyl)cyclobutanecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benzyl 3-(hydroxyMethyl)cyclobutanecarboxylate

There total 12 articles about benzyl 3-(hydroxyMethyl)cyclobutanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(1r,3r)‐3‐[(benzyloxy)carbonyl]cyclobutane‐1‐carboxylic acid → benzyl (1r,3r)‐3‐(hydroxymethyl)cyclobutane‐1‐carboxylate (939768-59-9)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

Reference yield: 69.0%

(1s,3s)‐3‐[(benzyloxy)carbonyl]cyclobutane‐1‐carboxylic acid → benzyl (1s,3s)‐3‐(hydroxymethyl)cyclobutane‐1‐carboxylate (939768-59-9)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;

Reference yield: 49.0%

benzyl 3-methylenecyclobutane-1-carboxylate (939768-58-8) → benzyl 3-(hydroxymethyl)cyclobutane-1-carboxylate (939768-59-9)

Guidance literature:

benzyl 3-methylenecyclobutane-1-carboxylate; With dimethylsulfide borane complex; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere; Cooling with ice;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 2h;

upstream raw materials:

3-methylenecyclobutanecarbonitrile

3-methylenecyclobutane-1-carboxylic acid

benzyl 3-methylenecyclobutane-1-carboxylate

Refernces