4-chloro-2-iodo-1-nitrobenzene

Base Information

• Chemical Name: 4-chloro-2-iodo-1-nitrobenzene
• CAS No.: 160938-18-1
• Molecular Formula: C6H3ClINO2
• Molecular Weight: 283.453
• Hs Code.: 2904909090
• Mol file: 160938-18-1.mol

Synonyms:4-chloro-2-iodo-1-nitrobenzene;Benzene, 4-chloro-2-iodo-1-nitro-

Chemical Property of 4-chloro-2-iodo-1-nitrobenzene

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Boiling Point: 309.263°C at 760 mmHg
• Flash Point: 140.838°C
• PSA: 45.82000
• Density: 2.095g/cm³
• LogP: 3.37600
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Chloro-2-iodo-1-nitrobenzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-chloro-2-iodo-1-nitrobenzene

There total 10 articles about 4-chloro-2-iodo-1-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-chloro-2-nitrobenzoic acid (2516-95-2) → 1-iodo-5-chloro-2-nitrobenzene (160938-18-1)

Guidance literature:

With copper(l) iodide; oxygen; In dimethyl sulfoxide; at 160 ℃; for 30h; under 760.051 Torr; Schlenk technique; Sealed tube;

DOI:10.1021/acs.joc.5b02873

Reference yield: 91.0%

5-chloro-2-nitroaniline (1635-61-6) → 1-iodo-5-chloro-2-nitrobenzene (160938-18-1)

Guidance literature:

With potassium nitrite; hydrogen iodide; dimethyl sulfoxide; In water; at 35 ℃; for 0.166667h;

DOI:10.1139/v05-026

Reference yield: 18.0%

3,5-dimethyl-1H-pyrazole (67-51-6) + 2-bromo-4-chloro-1-nitrobenzene (63860-31-1) → 1-iodo-5-chloro-2-nitrobenzene (160938-18-1) + 3,3'-dibromo-4,4'-dinitrobiphenyl (1059705-77-9) + 5,5'-dichloro-2,2'-dinitro-1,1'-biphenyl (19036-42-1) + 1-(5-chloro-2-nitrophenyl)-3,5-dimethylpyrazole (60418-33-9)

Guidance literature:

With potassium phosphate; copper(l) iodide; In toluene; at 110 ℃; for 20h; Further byproducts.;

DOI:10.1002/adsc.200700133

upstream raw materials:

5-chloro-2-nitroaniline

2,4-dichloronitrobenzene

2,4-Dichloroaniline

1,3-Dichlorobenzene

Downstream raw materials:

3-(5-Chloro-2-nitro-phenyl)-1H-indole

7-(5-Chloro-2-nitrophenyl)-6-heptynoic acid methyl ester

6-(5-Chloro-2-nitrophenyl)-5-hexynoic acid methyl ester

methyl 7-(2-amino-5-chlorophenyl)hept-6-ynoate

Refernces

• 1、 Fu, Zhengjiang,Jiang, Ligao,Zuo, Qianming,Li, Zhaojie,Liu, Yanzhu,Wei, Zhenhong,Cai, Hu. "Inexpensive NaX (X = I, Br, Cl) as a halogen donor in the practical Ag/Cu-mediated decarboxylative halogenation of aryl carboxylic acids under aerobic conditions". supporting information. p. 5416 - 5421. Retrieved 2018/08/12.
• 2、 Li, Xinyu,Li, Cheng,Zhang, Wenjing,Lu, Xiang,Han, Shiqing,Hong, Ran. "Highly stereoselective 7-endo-trig /ring contraction cascade to construct pyrrolo[1,2- a ]quinoline derivatives". supporting information; experimental part. p. 1696 - 1699. Retrieved 2010/09/05.