6-chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine

Base Information

• Chemical Name: 6-chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine
• CAS No.: 1000341-55-8
• Molecular Formula: C7H4ClIN2
• Molecular Weight: 278.48
• Mol file: 1000341-55-8.mol

Synonyms:6-chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine;1H-Pyrrolo[3,2-c]pyridine, 6-chloro-3-iodo-

Chemical Property of 6-chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine

Chemical Property:

• PSA: 28.68000
• LogP: 2.82090
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

6-Chloro-3-iodo-5-azaindole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine

There total 1 articles about 6-chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

6-chloro-1H-pyrrolo[3,2-c]pyridine (74976-31-1) → 6-chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine (1000341-55-8)

Guidance literature:

With iodine; potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 0.833333h;

Reference yield: 76.0%

6-chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine (1000341-55-8) + p-toluenesulfonyl chloride (98-59-9) → C14H10ClIN2O2S

Guidance literature:

6-chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.166667h;

p-toluenesulfonyl chloride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

Reference yield:

6-chloro-3-iodo-1H-pyrrolo[3,2-c]pyridine (1000341-55-8) → C17H15ClN2O2S

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

1.2: 0.5 h / 20 °C

2.1: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II)-dichloromethane complex; caesium carbonate / 1,4-dioxane; water / 1 h / 100 °C

With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II)-dichloromethane complex; sodium hydride; caesium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

6-chloro-1H-pyrrolo[3,2-c]pyridine

Refernces

• 1、 Bryan, Marian C.,Falsey, James R.,Frohn, Mike,Reichelt, Andreas,Yao, Guomin,Bartberger, Michael D.,Bailis, Julie M.,Zalameda, Leeanne,Miguel, Tisha San,Doherty, Elizabeth M.,Allen, John G.. "N-substituted azaindoles as potent inhibitors of Cdc7 kinase". . p. 2056 - 2060. Retrieved 2013/05/09.