2-(Quinolin-5-Yl)acetic acid

Base Information

• Chemical Name: 2-(Quinolin-5-Yl)acetic acid
• CAS No.: 152150-03-3
• Molecular Formula: C11H9NO2
• Molecular Weight: 187.198
• Mol file: 152150-03-3.mol

Synonyms:2-(QUINOLIN-5-YL)ACETIC ACID;RARECHEM AL MS 0477;5-Quinolineacetic acid

Chemical Property of 2-(Quinolin-5-Yl)acetic acid

Chemical Property:

• Vapor Pressure: 9.69E-07mmHg at 25°C
• Melting Point: 207 °C
• Boiling Point: 388.8°C at 760 mmHg
• PKA: 3.46±0.30(Predicted)
• Flash Point: 188.9°C
• PSA: 50.19000
• Density: 1.297g/cm³
• LogP: 1.86190

Purity/Quality:

98.5% ^*data from raw suppliers

2-(Quinolin-5-yl)aceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Quinolin-5-Yl)acetic acid

There total 2 articles about 2-(Quinolin-5-Yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromoquinoline (4964-71-0) → C11H9NO2 (152150-03-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene / tetrahydrofuran / 20 - 50 °C

2: hydrogenchloride; acetic acid / Reflux

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; acetic acid; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2011.01.046

Reference yield:

C15H17NO2 → C11H9NO2 (152150-03-3)

Guidance literature:

With hydrogenchloride; acetic acid; Reflux;

DOI:10.1016/j.bmcl.2011.01.046

upstream raw materials:

5-bromoquinoline

Refernces