ethyl 3-(5-(3-chloro-2-fluorobenzyl)-2,4-dimethoxyphenyl)-3-oxopropanoate

Base Information

Chemical Name:ethyl 3-(5-(3-chloro-2-fluorobenzyl)-2,4-dimethoxyphenyl)-3-oxopropanoate
CAS No.:949465-81-0
Molecular Formula:C20H20ClFO5
Molecular Weight:394.827
Hs Code.:
Mol file:949465-81-0.mol

Synonyms:ethyl 3-(5-(3-chloro-2-fluorobenzyl)-2,4-dimethoxyphenyl)-3-oxopropionate;

Suppliers and Price of ethyl 3-(5-(3-chloro-2-fluorobenzyl)-2,4-dimethoxyphenyl)-3-oxopropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 5 raw suppliers

Chemical Property of ethyl 3-(5-(3-chloro-2-fluorobenzyl)-2,4-dimethoxyphenyl)-3-oxopropanoate

Chemical Property:

Boiling Point:507.4±50.0 °C(Predicted)
PKA:10.81±0.50(Predicted)
PSA：61.83000
Density:1.243±0.06 g/cm3(Predicted)
LogP:4.22300

Purity/Quality:: 99.9% ^*data from raw suppliers

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Pictogram(s):
Hazard Codes:

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Technology Process of ethyl 3-(5-(3-chloro-2-fluorobenzyl)-2,4-dimethoxyphenyl)-3-oxopropanoate

There total 11 articles about ethyl 3-(5-(3-chloro-2-fluorobenzyl)-2,4-dimethoxyphenyl)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 6148-64-7
ethyl potassium malonate

: 949465-81-0
ethyl 3-(5-(3-chloro-2-fluorobenzyl)-2,4-dimethoxyphenyl)-3-oxopropanoate

Guidance literature:: 5-(3-chloro-2-fluorobenzyl)-2,4-dimethoxybenzoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 0.5h;

ethyl potassium malonate; With magnesium chloride; In tetrahydrofuran; at 55 ℃; Product distribution / selectivity;

Reference yield: 85.0%

: 1551444-36-0
1-[5-(3-chloro-2-fluoro-benzyl)-2,4-dimethoxyphenyl]-ethanone

: 105-58-8,76619-83-5
Diethyl carbonate

: 949465-81-0
ethyl 3-(5-(3-chloro-2-fluorobenzyl)-2,4-dimethoxyphenyl)-3-oxopropanoate

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 19 - 25 ℃; Inert atmosphere;

Reference yield:

: 949465-80-9
5-(3-chloro-2-fluorobenzyl)-2,4-dimethoxybenzoic acid chloride

: 6148-64-7
ethyl potassium malonate

: 949465-81-0
ethyl 3-(5-(3-chloro-2-fluorobenzyl)-2,4-dimethoxyphenyl)-3-oxopropanoate

Guidance literature:: ethyl potassium malonate; With triethylamine; magnesium chloride; In tetrahydrofuran; ethyl acetate; at 0 - 70 ℃;

5-(3-chloro-2-fluorobenzyl)-2,4-dimethoxybenzoic acid chloride; In tetrahydrofuran; ethyl acetate; at 70 ℃; for 0.5h;