1-Cyclobutyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Base Information

• Chemical Name: 1-Cyclobutyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
• CAS No.: 1002309-48-9
• Molecular Formula: C13H21BN2O2
• Molecular Weight: 248.133
• Hs Code.: 2934999090
• Mol file: 1002309-48-9.mol

Synonyms:1-cyclobutyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;

Chemical Property of 1-Cyclobutyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Chemical Property:

• Boiling Point: 370.218 °C at 760 mmHg
• PKA: 3.33±0.12(Predicted)
• Flash Point: 177.702 °C
• PSA: 36.28000
• Density: 1.143 g/cm³
• LogP: 1.90730
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Cyclobutyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Cyclobutyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

There total 2 articles about 1-Cyclobutyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.21%

pyrazole-4-boronic acid pinacol ester (269410-08-4) + Bromocyclobutane (4399-47-7) → 1-cyclobutyl-4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)-1H-pyrazole (1002309-48-9)

Guidance literature:

pyrazole-4-boronic acid pinacol ester; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.333333h; Inert atmosphere;

Bromocyclobutane; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2h;

Reference yield:

→ 1-cyclobutyl-4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)-1H-pyrazole (1002309-48-9)

Guidance literature:

Reference yield: 94.0%

1-cyclobutyl-4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)-1H-pyrazole (1002309-48-9) + ethyl 3-fluoro-5-nitro-2-{[(trifluoromethyl)sulfonyl]oxy}-benzoate → ethyl 2-(1-cyclobutyl-1H-pyrazol-4-yl)-3-fluoro-5-nitrobenzoate

Guidance literature:

With dichlorobis(triphenylphosphine)palladium(II); potassium carbonate; In 1,2-dimethoxyethane; water; at 100 ℃; for 1h; Inert atmosphere;

upstream raw materials:

pyrazole-4-boronic acid pinacol ester

Bromocyclobutane

Refernces

• 1、 -. "TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE". Page/Page column 96. . Retrieved 2017/10/18.