ALMAC B10505

Base Information

• Chemical Name: ALMAC B10505
• CAS No.: 690261-84-8
• Molecular Formula: C13H21N3O2S
• Molecular Weight: 283.395
• Mol file: 690261-84-8.mol

Synonyms:ALMAC B10505

Chemical Property of ALMAC B10505

Chemical Property:

• Boiling Point: 430.2±38.0 °C(Predicted)
• PKA: 5.00±0.10(Predicted)
• PSA: 96.69000
• Density: 1.211±0.06 g/cm3(Predicted)
• LogP: 3.35890

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl4-(2-aminothiazol-4-yl)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ALMAC B10505

There total 1 articles about ALMAC B10505 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

thiourea (17356-08-0) + 4-Bromoacetyl-1-(t-butoxycarbonyl)piperidine (301221-79-4) → 4-(2-amino-thiazol-4-yl)-piperidine-1-carboxylic acid tert-butyl ester (690261-84-8)

Guidance literature:

With potassium carbonate; In ethanol; at 60 ℃; for 8h;

Reference yield:

4-(2-amino-thiazol-4-yl)-piperidine-1-carboxylic acid tert-butyl ester (690261-84-8) + 2-chloro-6-fluoro-phenylacetic acid (37777-76-7) → 4-{2-[2-(2-chloro-6-fluoro-phenyl)-acetylamino]-thiazol-4-yl}-piperidine-1-carboxylic acid tert-butyl ester (1429841-23-5)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h;

Reference yield:

4-(2-amino-thiazol-4-yl)-piperidine-1-carboxylic acid tert-butyl ester (690261-84-8) + benzyl chloroformate (501-53-1,94274-21-2) → C21H27N3O4S (690261-85-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

upstream raw materials:

thiourea

4-Bromoacetyl-1-(t-butoxycarbonyl)piperidine

Downstream raw materials:

C₂₁H₂₇N₃O₄S

4-{2-[2-(2-chloro-6-fluoro-phenyl)-acetylamino]-thiazol-4-yl}-piperidine-1-carboxylic acid tert-butyl ester