4-Bromophenylalanine Hydrochloride Salt

Base Information

• Chemical Name: 4-Bromophenylalanine Hydrochloride Salt
• CAS No.: 122839-59-2
• Molecular Formula: C9H10BrNO2.ClH
• Molecular Weight: 280.54614
• Hs Code.: 2922499990
• Mol file: 122839-59-2.mol

Synonyms:(S)-2-amino-3-(4-bromophenyl)propanoic acid hydrochloride;

Chemical Property of 4-Bromophenylalanine Hydrochloride Salt

Chemical Property:

• PSA: 63.32000
• LogP: 2.90580

Purity/Quality:

98%,99%, ^*data from raw suppliers

H-Phe(4-Br)-OH.HCl 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromophenylalanine Hydrochloride Salt

There total 4 articles about 4-Bromophenylalanine Hydrochloride Salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

t-butyl 3-(4-bromophenyl)-2-(diphenylmethyleneamino)propanoate (1262785-54-5) → 4-bromophenylalanine-hydrochloride (108540-72-3,122839-59-2,122852-33-9)

Guidance literature:

With hydrogenchloride; In water; Reflux;

Reference yield:

diethyl (acetylamino)<(4-bromophenyl)methyl>propanedioate (71078-92-7) → 4-bromophenylalanine-hydrochloride (108540-72-3,122839-59-2,122852-33-9)

Guidance literature:

With hydrogenchloride; acetic acid; Heating;

Reference yield:

1-bromomethyl-4-bromobenzene (589-15-1) → 4-bromophenylalanine-hydrochloride (108540-72-3,122839-59-2,122852-33-9)

Guidance literature:

Multi-step reaction with 2 steps

2: HCl,CH₃COOH / Heating

With hydrogenchloride; acetic acid;

upstream raw materials:

diethyl (acetylamino)<(4-bromophenyl)methyl>propanedioate

1-bromomethyl-4-bromobenzene

2-acetylaminomalonic acid diethyl ester

t-butyl 3-(4-bromophenyl)-2-(diphenylmethyleneamino)propanoate

Downstream raw materials:

N-α-Tosyl-4-bromphenylalanin

4-bromo-N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-phenylalanine

4-[3-Oxo-3-piperidin-1-yl-2-(toluene-4-sulfonylamino)-propyl]-benzamidine; hydriodide

4-[3-Oxo-3-piperidin-1-yl-2-(toluene-4-sulfonylamino)-propyl]-benzimidic acid ethyl ester; hydrochloride

Refernces

• 1、 Ortwine, Daniel F.,Malone, Thomas C.,Bigge, Christopher F.,Drummond, James T.,Humblet, Christine,et al.. "Generation of N-Methyl-D-aspartate Agonist and Competitive Antagonist Pharmacophore Models. Design and Synthesis of Phosphonoalkyl-Substituted Tetrahydroisoquinolines as Novel Antagonists". . p. 1345 - 1370. Retrieved 2007/10/02.
• 2、 Wagner,Horn,Richter,et al.. "Synthesis of antiproteolytically active Nα-arylsulphonylated amidinophenylalaninamides". . p. 597 - 603. Retrieved 2007/10/02.