Chemical Property of AT-406(AT406)
Chemical Property:
- Boiling Point:840.6±65.0 °C(Predicted)
- PKA:13.65±0.40(Predicted)
- PSA：117.83000
- Density:1.21
- LogP:4.57020
- Solubility.:≥27.65 mg/mL in DMSO; insoluble in H2O; ≥27 mg/mL in EtOH
- Purity/Quality:
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99%, *data from raw suppliers
SM406 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
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Description
AT-406 is an orally bioavailable Smac/DIABLO mimetic and antagonist of the inhibitor of apoptosis proteins (IAPs). It binds to XIAP, cIAP1, and cIAP2 proteins with Ki values of 66.4, 1.9, and 5.1 nM, respectively. It has been shown to inhibit cancer cell growth in various human cancer cell lines and to induce apoptosis in xenograft tumors in mice.
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Uses
AT-406 is a potent IAP (inhibitor of apoptosis protein) inhibitor of XIAP, cIAP1, and cIAP2 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, respectively. SM 406 is a potent and orally active antagonist of multiple inhibitor of apoptosis proteins (IAPs).
