4-Bromo-2-isopropylphenol

Base Information

• Chemical Name: 4-Bromo-2-isopropylphenol
• CAS No.: 26307-50-6
• Molecular Formula: C9H11BrO
• Molecular Weight: 215.09
• Hs Code.: 2908199090
• Mol file: 26307-50-6.mol

Synonyms:Phenol, 4-bromo-2-isopropyl- (6CI,8CI);

Chemical Property of 4-Bromo-2-isopropylphenol

Chemical Property:

• Melting Point: 48-49 °C(Solv: heptane (142-82-5))
• Boiling Point: 260.156 °C at 760 mmHg
• PKA: 9.91±0.18(Predicted)
• Flash Point: 111.139 °C
• PSA: 20.23000
• Density: 1.396 g/cm³
• LogP: 3.27810
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform, DMSO, Methanol

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-2-(1-methylethyl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Bromo-2-(1-methylethyl)phenol is used in the synthesis of biphenyl proteomimetics as estrogen receptor-α coactivator binding inhibitors. As well, used in the production of thyroid hormone receptor specific analogs.

Technology Process of 4-Bromo-2-isopropylphenol

There total 10 articles about 4-Bromo-2-isopropylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(1-methylethyl)phenol (88-69-7) → 4-bromo-2-isopropyl-phenol (26307-50-6)

Guidance literature:

With sodium hydroxide; bromine; In dichloromethane; at 15 - 20 ℃; for 0.75h;

Reference yield: 100.0%

2-(1-methylethyl)phenol (88-69-7) + tetra-n-butylammonium tribromide → 4-bromo-2-isopropyl-phenol (26307-50-6)

Guidance literature:

With hydrogenchloride; sodium sulfite; In diethyl ether; chloroform;

Reference yield: 88.0%

→ 4-bromo-2-isopropyl-phenol (26307-50-6)

Guidance literature:

upstream raw materials:

2-(1-methylethyl)phenol

2-isopropenylphenol

2-isopropylaniline

o-isopropylanisole

Downstream raw materials:

4-bromo-2-isopropyl-1-triisopropylsilanyloxybenzene

4-bromo-2-isopropylphenyl trifluoromethanesulfonate

4-bromo-2-isopropylanisole

1-benzyloxy-4-bromo-2-isopropylbenzene

Refernces

• 1、 -. "NOVEL COMPOUNDS AND THEIR USES AS THYROID HORMONE RECEPTOR AGONISTS". Page/Page column 26. . Retrieved 2020/09/08.
• 2、 -. "NOVEL PROCESS FOR SYNTHESIS OF A PHENOXY DIAMINOPYRIMIDINE COMPOUND". Page/Page column 12-13. . Retrieved 2019/11/12.