6-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one

Base Information

Chemical Name:6-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one
CAS No.:1245708-13-7
Molecular Formula:C7H5BrN2O2
Molecular Weight:229.033
Hs Code.:2934999090
DSSTox Substance ID:DTXSID00579706
Wikidata:Q82470317
Mol file:1245708-13-7.mol

Synonyms:6-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one;1245708-13-7;6-bromo-1H-pyrido[2,3-b][1,4]oxazin-2-one;MFCD15526939;SCHEMBL10197521;DTXSID00579706;SFSUNEUWRUJCDV-UHFFFAOYSA-N;VZB70813;AKOS016010834;AS-43050;SY129389;CS-0137813;A909984;1H-Pyrido[2,3-b][1,4]oxazin-2(3H)-one, 6-bromo-

Suppliers and Price of 6-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one
100mg
$ 975.00

TRC
6-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one
10mg
$ 120.00

Crysdot
6-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one 95+%
5g
$ 2054.00

Crysdot
6-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one 95+%
250mg
$ 267.00

Crysdot
6-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one 95+%
1g
$ 589.00

ChemScene
6-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one
1g
$ 665.00

ChemScene
6-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one
250mg
$ 290.00

Chemcia Scientific
6-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2-one 95%
0.5 G
$ 365.00

American Custom Chemicals Corporation
6-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE 95.00%
5MG
$ 500.05

Alichem
6-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one
1g
$ 595.00

Total 8 raw suppliers

Chemical Property of 6-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one

Chemical Property:

PSA：54.71000
LogP:1.26010
Storage Temp.:2-8°C
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:227.95344
Heavy Atom Count:12
Complexity:200

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(=O)NC2=C(O1)N=C(C=C2)Br
Uses 6-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one can be prepared as OGA inhibitors to treat diseases.

Technology Process of 6-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one

There total 4 articles about 6-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.5%

: 22118-09-8
2-bromoacetyl chloride

: 134577-43-8
3-amino-6-bromopyridin-2-ol

: 1245708-13-7
6-bromo-1h-pyrido[2,3-b][1 ,4]oxazin-2(3h)-one

Guidance literature:: With triethylamine; In tetrahydrofuran; at 10 - 35 ℃;

Reference yield: 45.0%

: 134577-43-8
3-amino-6-bromopyridin-2-ol

: 96-32-2
bromoacetic acid methyl ester

: 1245708-13-7
6-bromo-1h-pyrido[2,3-b][1 ,4]oxazin-2(3h)-one

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1-methyl-pyrrolidin-2-one; at 180 ℃; for 0.05h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/ml400527n

Reference yield:

: 20265-38-7
3-amino-2-methoxypyridine

: 1245708-13-7
6-bromo-1h-pyrido[2,3-b][1 ,4]oxazin-2(3h)-one

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 0 °C

2: water; hydrogen bromide / acetic acid / 1 h / 80 °C

3: triethylamine / tetrahydrofuran / 10 - 35 °C

With N-Bromosuccinimide; water; hydrogen bromide; triethylamine; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide;