8-((tert-Butoxycarbonyl)amino)-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid

Base Information

Chemical Name:8-((tert-Butoxycarbonyl)amino)-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid
CAS No.:130532-76-2
Molecular Formula:C₁₆H₂₁NO₄
Molecular Weight:291.347
Hs Code.:
DSSTox Substance ID:DTXSID90563659

Synonyms:130532-76-2;8-((tert-Butoxycarbonyl)amino)-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid;8-{[(tert-butoxy)carbonyl]amino}-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid;8-[(2-methylpropan-2-yl)oxycarbonylamino]-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid;8-[(tert-Butoxycarbonyl)amino]-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid;SCHEMBL803449;DTXSID90563659;8-((tert-Butoxycarbonyl)amino)-5,6,7,8-tetrahydronaphthalene-2-carboxylicacid;CS-0216101;N13946;EN300-3341520;Z1508690534;2-Naphthalenecarboxylic acid, 8-[[(1,1-dimethylethoxy)carbonyl]amino]-5,6,7,8-tetrahydro-

Suppliers and Price of 8-((tert-Butoxycarbonyl)amino)-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 8-((tert-Butoxycarbonyl)amino)-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:291.14705815
Heavy Atom Count:21
Complexity:402

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1CCCC2=C1C=C(C=C2)C(=O)O

Technology Process of 8-((tert-Butoxycarbonyl)amino)-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid

There total 3 articles about 8-((tert-Butoxycarbonyl)amino)-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.4%

: 24424-99-5
di-tert-butyl dicarbonate

: 130532-64-8,2565792-56-3
(RS)-8-Amino-5,6,7,8-tetrahydronaphth-2-oic Acid Hydrochloride

: 130532-76-2
(RS)-8-<(tert-Butoxy)carbonylamino>-5,6,7,8-tetrahydronaphtho-2-oic Acid

Guidance literature:: With sodium carbonate; In 1,4-dioxane; Ambient temperature;
DOI:10.1002/hlca.19930760414

Reference yield:

: 89781-52-2
8-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid

: 130532-76-2
(RS)-8-<(tert-Butoxy)carbonylamino>-5,6,7,8-tetrahydronaphtho-2-oic Acid

Guidance literature:: Multi-step reaction with 3 steps

1: 83.4 percent / NH₂OH / methanol / 2 h / 60 °C

2: 87.2 percent / H₂ / 5percent Pd/C / methanol / 5 h / 25 °C / 3000.2 Torr

3: 83.4 percent / 1M aq. Na₂CO₃ / dioxane / Ambient temperature

With hydrogen; hydroxylamine; sodium carbonate; palladium on activated charcoal; In 1,4-dioxane; methanol;
DOI:10.1002/hlca.19930760414

Reference yield:

: 130532-67-1
8-(Hydroxyimino)-5,6,7,8-tetrahydronaphth-2-oic Acid

: 130532-76-2
(RS)-8-<(tert-Butoxy)carbonylamino>-5,6,7,8-tetrahydronaphtho-2-oic Acid

Guidance literature:: Multi-step reaction with 2 steps

1: 87.2 percent / H₂ / 5percent Pd/C / methanol / 5 h / 25 °C / 3000.2 Torr

2: 83.4 percent / 1M aq. Na₂CO₃ / dioxane / Ambient temperature

With hydrogen; sodium carbonate; palladium on activated charcoal; In 1,4-dioxane; methanol;
DOI:10.1002/hlca.19930760414