3-(4-Chlorophenyl)pyrrolidine hydrochloride

Base Information

• Chemical Name: 3-(4-Chlorophenyl)pyrrolidine hydrochloride
• CAS No.: 1095545-18-8
• Molecular Formula: C₁₀H₁₂ClN*ClH
• Molecular Weight: 218.126
• Mol file: 1095545-18-8.mol

Synonyms:3-(4-CHLORO-PHENYL) PYRROLIDINE HCL;3-(4-CHLOROPHENYL)PYRROLIDINE HYDROCHLORIDE

Chemical Property of 3-(4-Chlorophenyl)pyrrolidine hydrochloride

Chemical Property:

• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3-(4-Chlorophenyl)pyrrolidineHydrochloride ^*data from reagent suppliers

Safty Information:

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Technology Process of 3-(4-Chlorophenyl)pyrrolidine hydrochloride

There total 1 articles about 3-(4-Chlorophenyl)pyrrolidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-tert-butyl 3-(4-chlorophenyl)pyrrolidine-1-carboxylate (171897-39-5) → (3R)-3-(4-chlorophenyl)pyrrolidine hydrochloride (1095545-18-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

3-(4-chlorophenyl)pyrrolidine hydrochloride (1095545-18-8) → tert-butyl 3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidine-1-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C

2: chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); potassium acetate / 1,4-dioxane / 3 h / 70 °C / Microwave irradiation; Inert atmosphere

With chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); potassium acetate; triethylamine; In 1,4-dioxane; dichloromethane;

Reference yield:

3-(4-chlorophenyl)pyrrolidine hydrochloride (1095545-18-8) → tert-butyl 3-(2′-(1-(4-methoxybenzyl)-1H-tetrazol-5-yl)-3′-sulfamoyl-[1,1′-biphenyl]-4-yl)pyrrolidine-1-carboxylate

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 20 °C

2: chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); potassium acetate / 1,4-dioxane / 3 h / 70 °C / Microwave irradiation; Inert atmosphere

3: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; ethanol / 2 h / 120 °C / Microwave irradiation; Sealed tube; Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); potassium acetate; potassium carbonate; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; water;

upstream raw materials:

(R)-tert-butyl 3-(4-chlorophenyl)pyrrolidine-1-carboxylate

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